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Titolo:
Early stress and genetic influences on hypothalamic-pituitary-adrenal axisfunctioning in adulthood
Autore:
King, JA; Edwards, E;
Indirizzi:
Univ Massachusetts, Med Ctr, Dept Psychiat, Behav Neurosci Program, Worcester, MA 01655 USA Univ Massachusetts Worcester MA USA 01655 rogram, Worcester, MA 01655 USA Univ Maryland, Dept Pharmaceut Sci, Pharmacol & Toxicol Program, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 col Program, Baltimore, MD 21201 USA
Titolo Testata:
HORMONES AND BEHAVIOR
fascicolo: 2, volume: 36, anno: 1999,
pagine: 79 - 85
SICI:
0018-506X(199910)36:2<79:ESAGIO>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
MATERNAL-DEPRIVATION; LEARNED HELPLESSNESS; ANIMAL-MODELS; NEONATAL RAT; INFANT RAT; DEPRESSION; BEHAVIOR; ACTH; BASAL; BRAIN;
Keywords:
HPA axis; stress; footshock; maternal deprivation; cold stress;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: King, JA Univ Massachusetts, Med Ctr, Dept Psychiat, Behav Neurosci Program, Worcester, MA 01655 USA Univ Massachusetts Worcester MA USA 01655 orcester, MA 01655 USA
Citazione:
J.A. King e E. Edwards, "Early stress and genetic influences on hypothalamic-pituitary-adrenal axisfunctioning in adulthood", HORMONE BEH, 36(2), 1999, pp. 79-85

Abstract

During early development, environmental challenges set the stage for permanent changes in the functioning of the pituitary-adrenal stress response. Since these data have been reported almost exclusively in single rat strainsthe role of phenotypic and genotypic factors in shaping the stress response is relatively unknown. This study examined whether the phenotypic/geneticprofile of the rat influences the long-term response to challenge after early exposure to stress. Two strains of Sprague-Dawley rats were used in this study: one is a stress-induced animal model of "learned helpless" (LH) behavior and the other a resistant strain developed through selective breeding. Stress-induced adrenocorticotropic hormone (ACTH) and corticosterone release was monitored in adult congenital learned helpless (cLH) rats and congenital non-learned helpless (cNLH) rats. The rats were exposed to cold stress or maternal deprivation ton either postnatal day 7 or day 21). After theearly acute stress exposure, animals remained undisturbed until challengedin adulthood (day 90) with footshock stress. In cLH animals (adults) earlycold stress (particularly after acute stress on postnatal day 21) and maternal deprivation stress resulted in an enhancement of stress-induced ACTH release compared to nonstressed cLH and cNLH controls. In contrast, adrenal responsiveness was generally suppressed in cLH animals that were acutely stressed with cold stress or maternal deprivation stress early in life. The above results suggest that the genetic/phenotypic profile of the animal is adeterminant in the changes observed in the adult stress response after early exposure to stressors. (C) 1999 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 03:51:49