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Titolo:
Effects of microdialysis application of monoamines on the EEG and behavioural states in the cat mesopontine tegmentum
Autore:
Crochet, S; Sakai, K;
Indirizzi:
Univ Lyon 1, Dept Expt Med, INSERM, U480, F-69373 Lyon, France Univ Lyon 1 Lyon France F-69373 Med, INSERM, U480, F-69373 Lyon, France
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 10, volume: 11, anno: 1999,
pagine: 3738 - 3752
SICI:
0953-816X(199910)11:10<3738:EOMAOM>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
FREELY MOVING CATS; DORSAL PONTINE TEGMENTUM; NUCLEUS BASALIS NEURONS; RAPHE UNIT-ACTIVITY; SLEEP-WAKING CYCLE; NON-CHOLINERGIC NEURONS; GUINEA-PIG BRAIN; PARADOXICAL SLEEP; REM-SLEEP; IN-VITRO;
Keywords:
catecholamines; histamine; paradoxical sleep; serotonin; wakefulness;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
121
Recensione:
Indirizzi per estratti:
Indirizzo: Sakai, K Univ Lyon 1, Dept Expt Med, INSERM, U480, 8 Ave Rockefeller, F-69373 Lyon,France Univ Lyon 1 8 Ave Rockefeller Lyon France F-69373 73 Lyon,France
Citazione:
S. Crochet e K. Sakai, "Effects of microdialysis application of monoamines on the EEG and behavioural states in the cat mesopontine tegmentum", EUR J NEURO, 11(10), 1999, pp. 3738-3752

Abstract

The peri-locus coeruleus alpha (peri-LC alpha) of the mediodorsal pontine tegmentum contains cholinergic and non-cholinergic neurons, and is critically implicated in the regulation of both wakefulness and paradoxical sleep (PS). The peri-LC alpha receives dense monaminergic (adrenergic, noradrenergic, serotonergic, dopaminergic and histaminergic) afferent projections, butlittle is known about their exact roles in the control of sleep-wake cycles. We have therefore examined the in vivo effects of microdialysis application of monoamines to the peri-LC alpha and adjacent cholinergic and non-cholinergic tegmental structures on behavioural states and the electroencephalogram (EEG) in freely moving cats. Norepinephrine, epinephrine and dopamineselectively inhibited PS and induced PS without atonia when applied to thecaudal part of the peri-LC alpha, which mainly contains non-cholinergic descending neurons, whereas histamine and serotonin had no effect at this site. In the rostral part of the peri-LC alpha and the adjacent X area (nucleus tegmenti pedunculopontinus, pars compacta), which contain many ascending cholinergic neurons, norepinephrine and epinephrine suppressed PS with a significant increase in waking and a decrease in slow-wave sleep, as expressed by a marked decrease in the power of the cortical and hippocampal delta (0.5-2.5 Hz) and cortical alpha (8-14 Hz) bands, and an increase in the cortical gamma (30-60 H) band. At these sites, histamine had similar waking andEEG-desynchronizing effects, but never suppressed PS, while dopamine and serotonin had no effects. These findings indicate a special importance of the adrenergic, noradrenergic and dopaminergic systems in the inhibitory or permissive mechanisms of PS, and of the adrenergic, noradrenergic and histaminergic systems in th control of behavioral and EEG arousal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 16:31:44