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Titolo:
Differential expression of the presynaptic cytomatrix protein bassoon among ribbon synapses in the mammalian retina
Autore:
Brandstatter, JH; Fletcher, EL; Garner, CC; Gundelfinger, ED; Wassle, H;
Indirizzi:
Max Planck Inst Hirnforsch, Abt Neuroanat, D-60528 Frankfurt, Germany Max Planck Inst Hirnforsch Frankfurt Germany D-60528 Frankfurt, Germany Univ Alabama, Dept Neurobiol, Birmingham, AL 35213 USA Univ Alabama Birmingham AL USA 35213 Neurobiol, Birmingham, AL 35213 USA Leibniz Inst Neurobiol, D-39118 Magdeburg, Germany Leibniz Inst NeurobiolMagdeburg Germany D-39118 9118 Magdeburg, Germany
Titolo Testata:
EUROPEAN JOURNAL OF NEUROSCIENCE
fascicolo: 10, volume: 11, anno: 1999,
pagine: 3683 - 3693
SICI:
0953-816X(199910)11:10<3683:DEOTPC>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYNAPTIC-VESICLE FUSION; ELECTRON-MICROSCOPIC ANALYSIS; INNER PLEXIFORM LAYER; RAT RETINA; CALCIUM CHANNELS; BIPOLAR CELLS; IMMUNOCYTOCHEMICAL LOCALIZATION; NEUROTRANSMITTER RELEASE; NEURONAL SUBPOPULATIONS; VERTEBRATE RETINA;
Keywords:
exocytosis; immunoelectron microscopy; rabbit retina; rat retina; synaptic proteins;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
56
Recensione:
Indirizzi per estratti:
Indirizzo: Brandstatter, JH Max Planck Inst Hirnforsch, Abt Neuroanat, Deutschordenstr 46, D-60528 Frankfurt, Germany Max Planck Inst Hirnforsch Deutschordenstr46 Frankfurt Germany D-60528
Citazione:
J.H. Brandstatter et al., "Differential expression of the presynaptic cytomatrix protein bassoon among ribbon synapses in the mammalian retina", EUR J NEURO, 11(10), 1999, pp. 3683-3693

Abstract

Bassoon is a 420-kDa presynaptic protein which is highly concentrated at the active zones of nerve terminals of conventional synapses, both excitatory glutamatergic and inhibitory GABAergic, in rat brain. It is thought to beinvolved in the organization of the cytomatrix at the site of neurotransmitter release. In the retina, there are two structurally and functionally distinct types of synapses: ribbon and conventional synapses Antibodies against bassoon were applied to sections of rat and rabbit retina. Strong punctate immunofluorescence was found in the outer and inner plexiform layers. Using pre- and post-embedding immunostaining and electron microscopy, bassoonwas localized in the outer plexiform layer at ribbon synapses formed by rods and cones but was absent from basal synaptic contacts formed by cones. In the inner plexiform layer a different picture emerged. Ads in the brain, bassoon was found at conventional inhibitory GABAergic synapses, made by amacrine cells, but it was absent from the bipolar cell ribbon synapses. These data demonstrate differences in the molecular composition of the presynaptic apparatuses of outer and inner plexiform layer ribbon synapses. Thus, differential equipment with cytomatrix proteins may account for the functional differences observed between the two types of ribbon synapses in the retina.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 21:18:58