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Titolo:
Consistency and efficacy of cetirizine (10 mg) versus ebastine (20 mg) at 4 h on skin reactivity
Autore:
Purohit, A; Duvernelle, C; Melac, M; Benabdesselam, O; Pauli, G; Frossard, N;
Indirizzi:
Fac Pharm, INSERM U425, Illkirch Graffenstaden, France Fac Pharm IllkirchGraffenstaden France Illkirch Graffenstaden, France Hop Univ, INSERM U425, Serv Pneumol, Strasbourg, France Hop Univ Strasbourg France NSERM U425, Serv Pneumol, Strasbourg, France UCB Pharma, Nanterre, France UCB Pharma Nanterre FranceUCB Pharma, Nanterre, France
Titolo Testata:
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
fascicolo: 8, volume: 55, anno: 1999,
pagine: 589 - 592
SICI:
0031-6970(199910)55:8<589:CAEOC(>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHRONIC IDIOPATHIC URTICARIA; PHARMACOLOGICAL PROPERTIES; DOUBLE-BLIND; CUTANEOUS REACTIVITY; ALLERGIC DISORDERS; HISTAMINE; TERFENADINE; ASTEMIZOLE; PHARMACOKINETICS; ANTIHISTAMINE;
Keywords:
histamine skin prick test; antihistamine; allergy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Frossard, N Fac Pharm, INSERM U425, BP 24, Illkirch Graffenstaden, France Fac Pharm BP 24 Illkirch Graffenstaden France staden, France
Citazione:
A. Purohit et al., "Consistency and efficacy of cetirizine (10 mg) versus ebastine (20 mg) at 4 h on skin reactivity", EUR J CL PH, 55(8), 1999, pp. 589-592

Abstract

Objective: We compared the consistency and efficacy of the two antihistamines, cetirizine (10 mg) and ebastine (20 mg) on histamine skin reactivity 4h after treatment. Methods: Twenty-four healthy volunteers participated in a randomised double-blind cross-over study. The areas of wheals and flares induced by increasing (0, 5, 10, 50, 100, 200, 300 mg/ml) histamine concentrations, administered by prick tests, were measured before and 4 h after intake of cetirizineor ebastine. Results: Before treatment, concentration-response curves were similar and threshold concentrations identical (0.57 mg/ml and 0.57 mg/ml for cetirizine and ebastine, respectively). Both treatments exerted a significant effect. However, cetirizine was significantly more efficient than ebastine 20 mg (P < 0.01 both for wheals and flares). After cetirizine, the threshold concentration inducing a 3-mm(2) wheal was significantly higher (266 mg/ml) than after ebastine (77 mg/ml) (P < 0.01), and total inhibition of the wheal was obtained in 18 of 24 patients for cetirizine and in 4 of 24 for ebastine(P < 0.001). The variation coefficient for the wheal reaction was 31% for cetirizine and 159% for ebastine, indicating a much lower variability aftercetirizine. Conclusion: Our study shows clearly that the efficacy of a single therapeutic dosage of cetirizine is greater and consistently better than that of ebastine for suppression of cutaneous reactivity to histamine 4 h after treatment in healthy volunteers. The need for ebastine to metabolise into the active carebastine might explain this difference.

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Documento generato il 16/01/21 alle ore 11:09:35