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Titolo:
Diversity of nucleotide sequences in hypervariable region 1 of hepatitis Cvirus in Japanese patients with chronic hepatitis C of unknown mode of transmission
Autore:
Toyoda, H; Fukuda, Y; Hayakawa, T; Kumada, T; Nakano, S; Takamatsu, J; Saito, H;
Indirizzi:
Nagoya Univ, Sch Med, Dept Internal Med 2, Showa Ku, Nagoya, Aichi 4668550, Japan Nagoya Univ Nagoya Aichi Japan 4668550 a Ku, Nagoya, Aichi 4668550, Japan Nagoya Univ, Sch Med, Dept Transfus Med, Showa Ku, Nagoya, Aichi 4668550, Japan Nagoya Univ Nagoya Aichi Japan 4668550 a Ku, Nagoya, Aichi 4668550, Japan Nagoya Univ, Sch Med, Dept Internal Med 1, Showa Ku, Nagoya, Aichi 4668550, Japan Nagoya Univ Nagoya Aichi Japan 4668550 a Ku, Nagoya, Aichi 4668550, Japan Ogaki Municipal Hosp, Dept Gastroenterol, Ogaki, Japan Ogaki Municipal Hosp Ogaki Japan Hosp, Dept Gastroenterol, Ogaki, Japan
Titolo Testata:
DIGESTIVE DISEASES AND SCIENCES
fascicolo: 10, volume: 44, anno: 1999,
pagine: 1944 - 1949
SICI:
0163-2116(199910)44:10<1944:DONSIH>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; INTRAFAMILIAL TRANSMISSION; CHRONIC INFECTION; BLOOD-DONORS; NON-A; RNA; HCV; GENOTYPES; SUBTYPES; SUPERINFECTION;
Keywords:
hepatitis C virus; hypervariable region 1; multiple infections; nosocomial infection;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
40
Recensione:
Indirizzi per estratti:
Indirizzo: Toyoda, H Nagoya Univ, Sch Med, Dept Internal Med 2, Showa Ku, 65 Tsuruma Cho, Nagoya, Aichi 4668550, Japan Nagoya Univ 65 Tsuruma Cho Nagoya Aichi Japan 4668550 550, Japan
Citazione:
H. Toyoda et al., "Diversity of nucleotide sequences in hypervariable region 1 of hepatitis Cvirus in Japanese patients with chronic hepatitis C of unknown mode of transmission", DIG DIS SCI, 44(10), 1999, pp. 1944-1949

Abstract

We evaluated the sequence diversity of the hypervariable region 1 (HVR1) of hepatitis C virus (HCV) in HCV-infected patients in whom the mode of transmission is unknown. The sequence diversity of HVR1 in 26 Japanese patientswith chronic MCV infection of unknown mode of transmission (UT) was compared with 17 patients with chronic posttransfusion hepatitis C in whom only asingle HCV infection had occurred (PH), and with 18 patients with hemophilia with chronic HCV infection who might have been multiply infected with HCV (HE). The diversity of HVR1 was evaluated by direct sequencing after PCR amplification of HVR1, The sequence diversity of HVR1 was 10.1 +/- 7.7% in UT. 2.7 +/- 2.8% in PI-I, and 14.6 +/- 6.9% in HE. The diversity of the patients with unknown transmission was greater than that of the posttransfusion hepatitis patients, and in some patients it was similar to that of multitransfused hemophiliac patients (UT vs PH, P = 0.0004; UT vs HEI P = 0.04; and HE vs PHI P < 0.0001). Multiple infections with HCV could have occurred frequently in patients with chronic HCV infection in whom the mode of transmission was unknown, which increased the sequence diversity of HVR1 of these patients.

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Documento generato il 28/11/20 alle ore 21:59:11