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Titolo:
In vivo regulation of somite differentiation and proliferation by Sonic Hedgehog
Autore:
Marcelle, C; Ahlgren, S; Bronner-Fraser, M;
Indirizzi:
CALTECH, Beckman Inst 139 74, Div Biol, Pasadena, CA 91125 USA CALTECH Pasadena CA USA 91125 st 139 74, Div Biol, Pasadena, CA 91125 USA
Titolo Testata:
DEVELOPMENTAL BIOLOGY
fascicolo: 2, volume: 214, anno: 1999,
pagine: 277 - 287
SICI:
0012-1606(19991015)214:2<277:IVROSD>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEURAL-TUBE; SCLEROTOME INDUCTION; PARAXIAL MESODERM; AVIAN EMBRYOS; CHICK-EMBRYO; EXPRESSION; NOTOCHORD; CELLS; SIGNALS; HOMOLOG;
Keywords:
Shh; somite; proliferation; BrdU; Pax-1; MyoD; Pax-3;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
36
Recensione:
Indirizzi per estratti:
Indirizzo: Marcelle, C CNRS, UMR 6545, LGPD, Inst Dev Biol, Campus Luminy,Case 907, F-13288 Marseille 9, France CNRS Campus Luminy,Case 907 Marseille France 9 ille 9, France
Citazione:
C. Marcelle et al., "In vivo regulation of somite differentiation and proliferation by Sonic Hedgehog", DEVELOP BIO, 214(2), 1999, pp. 277-287

Abstract

In vertebrates, somite differentiation is mediated in part by Sonic Hedgehog (Shh), secreted by the notochord and the floor plate. However, Shh-null mice display close to normal expression of molecular markers for dermomytome, myotome, and sclerotome, indicating that Shh might not be required for their initial induction. In this paper, we have addressed the capacity of Shh to regulate in vivo the expression of the somite differentiation markers Pax-1, MyoD, and Pax-3 after separation of paraxial mesoderm from axial structures. We show that Pax-1, which is lost under these experimental conditions, is rescued by Shh. In contrast, Shh maintains, but cannot induce MyoD expression, while Pax-3 expression is independent of the presence of axial structures or Shh. Finally, we demonstrate that Shh is a potent mitogen forsemitic cells, supporting the idea that it may serve to expand subpopulations of cells within the somite. (C) 1999 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 19:33:53