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Titolo:
Inhaled nitric oxide does not improve cardiac or pulmonary function in patients with an exacerbation of chronic obstructive pulmonary disease
Autore:
Baigorri, F; Joseph, D; Artigas, A; Blanch, L;
Indirizzi:
Hosp Sabadell, Intens Care Serv, Sabadell 08208, Spain Hosp Sabadell Sabadell Spain 08208 tens Care Serv, Sabadell 08208, Spain
Titolo Testata:
CRITICAL CARE MEDICINE
fascicolo: 10, volume: 27, anno: 1999,
pagine: 2153 - 2158
SICI:
0090-3493(199910)27:10<2153:INODNI>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
RESPIRATORY-DISTRESS-SYNDROME; RIGHT-VENTRICULAR-FUNCTION; END-EXPIRATORY PRESSURE; GAS-EXCHANGE RESPONSES; MECHANICAL VENTILATION; LUNG-DISEASE; INHALATION; FAILURE; HYPERTENSION; DYSFUNCTION;
Keywords:
mechanical ventilation; chronic obstructive pulmonary disease; heart catheterization; nitric oxide; hemodynamics; cardiac output; right ventricular function; thermodilution; critical illness; lung;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Baigorri, F Hosp Sabadell, Intens Care Serv, Parc Tauli S-N, Sabadell 08208, Spain Hosp Sabadell Parc Tauli S-N Sabadell Spain 08208 8208, Spain
Citazione:
F. Baigorri et al., "Inhaled nitric oxide does not improve cardiac or pulmonary function in patients with an exacerbation of chronic obstructive pulmonary disease", CRIT CARE M, 27(10), 1999, pp. 2153-2158

Abstract

Objective:To determine whether inhaled nitric oxide (NO) improves right ventricular function in mechanically ventilated patients with severe chronic obstructive pulmonary disease (COPD). Design: Open, prospective, controlled trial. Setting: General intensive care unit of a community hospital,Patients: Twelve patients with acute respiratory failure caused by acute exacerbation of COPD requiring mechanical ventilation. Interventions: insertion of a pulmonary artery catheter modified with a rapid response thermistor and a radial arterial catheter. Nitric oxide was then administered to the patient via a T piece placed between the Y piece of the ventilator and the endotracheal tube. Measurements and Main Results:Hemodynamic and gasometric variables were recorded before NO inhalation, during administration of inhaled NO (20 ppm, 20 mins), and 20 mins after NO discontinuation. Inhaled NO reduced pulmonaryartery pressure from 26 +/- 6 to 22 +/- 5 mm Hg (p = .0004), hut arterial oxygenation, cardiac output, and right ventricular ejection fraction remained unmodified (41% +/- 9% vs. 41% +/- 8%; not significant). calculated pulmonary vascular resistance decreased from 453 + 233 to 348 +/- 108 dyne sec/cm(5).m(2) (p = .02), and right ventricular volumes did not change. Subsequently, right ventricular end-systolic pressure/volume ratio decreased from 0.52 +/- 0.22 to 0.44 +/- 0.19 mm Hg/mL/m(2) (p = .01). No significant correlation was observed between the changes of pulmonary artery pressure (or pulmonary vascular resistance) and changes of right ventricular ejection fraction. Conclusion: Inhalation of NO does not seem to improve either right ventricular function or arterial oxygenation in patients with acute respiratory failure caused by acute exacerbation of COPD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 15:28:29