Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Effects of acrivastine, loratadine and cetirizine on histamine-induced wheal and flare responses
Autore:
Bayramgurler, D; Bilen, N; Apaydyn, R; Altintas, L; Sal, G; Dokmeci, S; Utkan, T;
Indirizzi:
Univ Kocaeli, Fac Med, Dept Dermatol, Izmit, Turkey Univ Kocaeli Izmit Turkey ocaeli, Fac Med, Dept Dermatol, Izmit, Turkey Univ Kocaeli, Fac Med, Dept Pharmacol, Izmit, Turkey Univ Kocaeli Izmit Turkey caeli, Fac Med, Dept Pharmacol, Izmit, Turkey Univ Istanbul, Fac Med, Dept Publ Hlth, Istanbul, Turkey Univ Istanbul Istanbul Turkey Fac Med, Dept Publ Hlth, Istanbul, Turkey
Titolo Testata:
CLINICAL AND EXPERIMENTAL DERMATOLOGY
fascicolo: 5, volume: 24, anno: 1999,
pagine: 407 - 411
SICI:
0307-6938(199909)24:5<407:EOALAC>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
H-1-RECEPTOR ANTAGONISTS; DOUBLE-BLIND; TERFENADINE; ASTEMIZOLE; SUPPRESSION; SKIN; SCH-29851; ANTIGEN; RELEASE; SAFETY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
20
Recensione:
Indirizzi per estratti:
Indirizzo: Bayramgurler, D Kocaeli Univ, Tip Fak, Dermatol ABD, TR-41900 Sopaliciftligi, Kocaeli, Turkey Kocaeli Univ Sopaliciftligi Kocaeli Turkey TR-41900 urkey
Citazione:
D. Bayramgurler et al., "Effects of acrivastine, loratadine and cetirizine on histamine-induced wheal and flare responses", CLIN EXP D, 24(5), 1999, pp. 407-411

Abstract

It is accepted that studies evaluating histamine-induced wheal and flare reactions in the skin represent a simple and reliable method for demonstrating pharmacodynamic activity and pharmacokinetics of the H-1-receptor antagonists, In this study, the effects of single oral doses of acrivastine (8 mg), loratadine (10 mg) and cetirizine (10 mg) on the histamine-induced whealand flare reactions were compared in 60 healthy volunteers, The wheal and flare responses were produced by prick test using 1% histamine solution. Measurements were performed before the ingestion of antihistamines (baseline values) and afterwards at 15, 30, 90, 240, 360 min and 24 h. The values obtained for each antihistamine were compared with each other and with baseline values. Cetirizine was found to be superior to acrivastine and loratadinefor the suppression of wheal and flare responses at 240, 360 min and 24 h (P < 0.05) and acrivastine was superior to the other two antihistamines forthe suppression of flare response at 30 min (P < 0.05). Our results indicate that a single dose of cetirizine provides a more effective and long acting suppression on wheal and flare reactions in urticaria when compared to acrivastine and loratadine.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 09:31:00