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Titolo:
Association between a CYP3A4 genetic variant and clinical presentation in African-American prostate cancer patients
Autore:
Paris, PL; Kupelian, PA; Hall, JM; Williams, TL; Levin, H; Klein, EA; Casey, G; Witte, JS;
Indirizzi:
Cleveland Clin Fdn, Lerner Res Inst, Dept Canc Biol, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 c Biol, Cleveland, OH 44195 USA Cleveland Clin Fdn, Dept Radiat Oncol, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 Oncol, Cleveland, OH 44195 USA Cleveland Clin Fdn, Dept Anat Pathol, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 Pathol, Cleveland, OH 44195 USA Cleveland Clin Fdn, Dept Urol, Cleveland, OH 44195 USA Cleveland Clin FdnCleveland OH USA 44195 t Urol, Cleveland, OH 44195 USA Case Western Reserve Univ, Dept Epidemiol & Biostat, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA PPGX Inc, La Jolla, CA 92037 USA PPGX Inc La Jolla CA USA 92037PPGX Inc, La Jolla, CA 92037 USA
Titolo Testata:
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
fascicolo: 10, volume: 8, anno: 1999,
pagine: 901 - 905
SICI:
1055-9965(199910)8:10<901:ABACGV>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
SURVIVAL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Paris, PL Cleveland Clin Fdn, Lerner Res Inst, Dept Canc Biol, NB40,9500 Euclid Ave,Cleveland, OH 44195 USA Cleveland Clin Fdn NB40,9500 Euclid Ave Cleveland OH USA 44195 A
Citazione:
P.L. Paris et al., "Association between a CYP3A4 genetic variant and clinical presentation in African-American prostate cancer patients", CANC EPID B, 8(10), 1999, pp. 901-905

Abstract

Prostate cancer incidence, clinical presentation, and mortality rates varyamong different ethnic groups. A genetic variant of CYP3A4, a gene involved in the oxidative deactivation of testosterone, has been associated recently with prostate cancer development in Caucasians, To further investigate this variant, we evaluated its genotype frequencies in different ethnic groups and its association,vith clinical presentation of prostate cancer in African Americans. CYP3A4 genotypes were assayed in healthy male Caucasian (n = 117), Hispanic (n = 121), African-American (n = 116), Chinese (n = 46), and Japanese (n = 34) volunteers using the TaqMan assay. The association between CYP3A4 genotype and prostate cancer presentation was determined in 174affected African-American men. Genotype frequency of the CYP3A4 variant differed substantially across ethnic groups, with African Americans much morelikely to carry one or two copies than any other group (two-sided P < 0.0001), Among African Americans, 46% (80 of 174) of men with prostate cancer were homozygous for the CYP3A4 variant, whereas only 28% (32 of 116) of African-American healthy volunteers were homozygous (two-sided P < 0.005), A consistent positive association was observed between being homozygous for theCYP3A4 variant in African-American prostate cancer patients and clinical characteristics. Men homozygous for the CYP3A4 variant were more likely to present with higher grade and stage of prostate cancer in a recessive model [odds ratio (OR), 1.7; 95% confidence interval (CI), 0.9-3.4]. This association was even stronger for men who were >65 years of age at diagnosis (n = 103; OR, 2.4; 95% CI, 1.1-5.4). In summary, the CYP3A4 genotype frequency in different ethnic groups broadly followed trends in prostate cancer incidence, presentation, and mortality in the United States. African-American prostate cancer patients had a higher frequency of being homozygous for the CYP3A4 variant than healthy African-American volunteers who were matched solely based on ethnicity. Among the patients, those who were homozygous for the CYP3A4 variant were more likely to present with clinically more advanced prostate cancer.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 14:49:43