Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INCREASED ATHEROSCLEROSIS IN MICE RECONSTITUTED WITH APOLIPOPROTEIN-ENULL MACROPHAGES
Autore:
FAZIO S; BABAEV VR; MURRAY AB; HASTY AH; CARTER KJ; GLEAVES LA; ATKINSON JB; LINTON MF;
Indirizzi:
VANDERBILT UNIV,SCH MED,DEPT MED,715 MED RES BLDG 2 NASHVILLE TN 37232 VANDERBILT UNIV,SCH MED,DEPT PATHOL NASHVILLE TN 37232 VANDERBILT UNIV,SCH MED,DEPT PHARMACOL NASHVILLE TN 37232
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 9, volume: 94, anno: 1997,
pagine: 4647 - 4652
SICI:
0027-8424(1997)94:9<4647:IAIMRW>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
BONE-MARROW TRANSPLANTATION; E-DEFICIENT MICE; APOPROTEIN-E; MOUSE MACROPHAGES; EXPRESSION; LESIONS; PROTEIN; CELLS; CHOLESTEROL; HYPERCHOLESTEROLEMIA;
Keywords:
HYPERLIPIDEMIA; BONE MARROW TRANSPLANTATION; FOAM CELLS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
S. Fazio et al., "INCREASED ATHEROSCLEROSIS IN MICE RECONSTITUTED WITH APOLIPOPROTEIN-ENULL MACROPHAGES", Proceedings of the National Academy of Sciences of the United Statesof America, 94(9), 1997, pp. 4647-4652

Abstract

Macrophage-derived foam cells express apolipoprotein E (apoE) abundantly in atherosclerotic lesions. To examine the physiologic role of apoE secretion by the macrophage in atherogenesis, bone marrow transplantation was used to reconstitute C57BL/6 mice with macrophages that wereeither null or wild type for the apoE gene, After 13 weeks on an atherogenic diet, C57BL/6 mice reconstituted with apoE null marrow developed 10-fold more atherosclerosis than controls in the absence of significant differences in serum cholesterol levels or lipoprotein profiles,ApoE expression was absent in the macrophage-derived foam cells of C57BL/6 mice reconstituted with apoE null marrow. Thus, lack of apoE expression by the macrophage promotes foam cell formation, These data support a protective role for apoE expression by the macrophage in early atherogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 06:24:52