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Titolo:
Atropine and ODQ antagonize tetanic fade induced by L-arginine in cats
Autore:
Cruciol-Souza, JM; Alves-Do-Prado, W;
Indirizzi:
Univ Estadual Maringa, Dept Farm & Farmacol, BR-87020900 Maringa, Parana, Brazil Univ Estadual Maringa Maringa Parana Brazil BR-87020900 BC Parana, Brazil Univ Estadual Londrina, Dept Ciencias Fisiol, Londrina, Parana, Brazil Univ Estadual Londrina Londrina Parana Brazil , Londrina, Parana, Brazil
Titolo Testata:
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
fascicolo: 10, volume: 32, anno: 1999,
pagine: 1277 - 1283
SICI:
0100-879X(199910)32:10<1277:AAOATF>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
NITRIC-OXIDE; ACETYLCHOLINE-RELEASE; POTENTIATION; PHARMACOLOGY; DIAPHRAGM; RECEPTORS; REVERSAL;
Keywords:
atropine; tetanic fade; skeletal muscle; nitric oxide; muscarinic receptors;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
21
Recensione:
Indirizzi per estratti:
Indirizzo: Alves-Do-Prado, W Univ Estadual Maringa, Dept Farm & Farmacol, Av Colombo 3690 Bloco K-80,Sala 6, BR-87020900 Maringa, Parana, Brazil Univ Estadual Maringa Av Colombo 3690 Bloco K-80,Sala 6 Maringa Parana Brazil BR-87020900 BC
Citazione:
J.M. Cruciol-Souza e W. Alves-Do-Prado, "Atropine and ODQ antagonize tetanic fade induced by L-arginine in cats", BRAZ J MED, 32(10), 1999, pp. 1277-1283

Abstract

Although it has been demonstrated that nitric oxide (NO) released from sodium nitrite induces tetanic fade in the cat neuromuscular preparations, theeffect of L-arginine on tetanic fade and its origin induced by NO have notbeen studied in these preparations. Furthermore, atropine reduces tetanic fade induced by several cholinergic and anticholinergic drugs in these preparations, whose mechanism is suggested to be mediated by the interaction ofacetylcholine with inhibitory presynaptic muscarinic receptors. The present study was conducted in cats to determine the effects of L-arginine alone or after pretreatment with atropine or 1H-[1,2,4]oxadiazole [4,3-a]quinoxalin-1-one (ODQ) on neuromuscular preparations indirectly stimulated at high frequency. Drugs were injected into the middle genicular artery. L-arginine(2 mg/kg) and S-nitroso-N-acetylpenicillamine (SNAP; 16 mu g/kg) induced tetanic fade. The N-omega-nitro-L-arginine (L-NOARG; 2 mg/kg) alone did not produce any effect, but reduced the tetanic fade induced by L-arginine. D-arginine (2 mg/kg) did not induce changes in tetanic fade. The tetanic fade induced by L-arginine or SNAP was reduced by previous injection of atropine(1.0 mu g/kg) or ODQ (15 mu g/kg). ODQ alone did not change tetanic fade. The data suggest that the NO-synthase-GC pathway participates in the L-arginine-induced tetanic fade in cat neuromuscular preparations. The tetanic fade induced by L-arginine probably depends on the action of NO at the presynaptic level. NO may stimulate guanylate cyclase increasing acetylcholine release and thereby stimulating presynaptic muscarinic receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 14:22:32