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Titolo:
Changes in extracellular glutamate and pressor response during muscle contraction following AMPA-receptor blockade in the RVLM and CVLM
Autore:
Lillaney, R; Maher, TJ; Chaiyakul, P; Ally, A;
Indirizzi:
Massachusetts Coll Pharm & Hlth Sci, Div Pharmaceut Sci, Boston, MA 02115 USA Massachusetts Coll Pharm & Hlth Sci Boston MA USA 02115 ton, MA 02115 USA Univ New England, Coll Osteopath Med, Dept Physiol, Biddeford, ME 04005 USA Univ New England Biddeford ME USA 04005 Physiol, Biddeford, ME 04005 USA Univ New England, Coll Osteopath Med, Dept Pharmacol, Biddeford, ME 04005 USA Univ New England Biddeford ME USA 04005 harmacol, Biddeford, ME 04005 USA Univ New England, Coll Osteopath Med, Dept Biochem, Biddeford, ME 04005 USA Univ New England Biddeford ME USA 04005 Biochem, Biddeford, ME 04005 USA
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 844, anno: 1999,
pagine: 164 - 173
SICI:
0006-8993(19991009)844:1-2<164:CIEGAP>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
ROSTRAL VENTROLATERAL MEDULLA; AMINO-ACID NEUROTRANSMITTERS; IN-VIVO MICRODIALYSIS; NON-NMDA RECEPTORS; MUSCULAR-CONTRACTION; BIOGENIC-AMINES; RELEASE; RAT; NEURONS; CYCLOTHIAZIDE;
Keywords:
rostral ventrolateral medulla; caudal ventrolateral medulla; excitatory amino acid; microdialysis; blood pressure;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
38
Recensione:
Indirizzi per estratti:
Indirizzo: Maher, TJ Massachusetts Coll Pharm & Hlth Sci, Div Pharmaceut Sci, 179 Longwood Ave,Boston, MA 02115 USA Massachusetts Coll Pharm & Hlth Sci 179 Longwood Ave Boston MA USA 02115
Citazione:
R. Lillaney et al., "Changes in extracellular glutamate and pressor response during muscle contraction following AMPA-receptor blockade in the RVLM and CVLM", BRAIN RES, 844(1-2), 1999, pp. 164-173

Abstract

We examined whether modulation of cardiovascular responses by administering 6-cyano-7-nitroquinoxaline-2,3- dione (CNQX, an AMPA-receptor antagonist)into the rostral (RVLM) or caudal (CVLM) ventrolateral medulla are mediated via changes in extracellular levels of glutamate. Microdialysis probes were inserted bilaterally into the RVLM or the CVLM. For the RVLM experiments(n = 8), muscle contraction for 2 min increased mean arterial pressure (MAP) and heart rate (HR) by 18 +/- 3 mmHg and 24 +/- 5 bpm, respectively. Extracellular glutamate concentrations increased from 1.5 +/- 0.3 to 4.3 +/- 0.9 ng/5 mu l during the contraction. Microdialysis of CNQX (1.0 mu M) for 30 min into the RVLM attenuated the increases in MAP, HR, and glutamate concentration in response to a muscle contraction (8 +/- 2 mmHg, 11 +/- 3 bpm, and 2.2 +/- 0.7 ng/5 mu l, respectively). Developed tensions did not changeduring contractions before and after CNQX. Microdialysis of CNQX into the CVLM (n = 8) potentiated the contraction-evoked responses in MAP (19 +/- 3 vs. 34 +/- 3 mmHg) and HR (25 +/- 4 vs. 49 +/- 5 bpm) without a change in developed tension. Following CNQX perfusion into the CVLM, the levels of extracellular glutamate in the CVLM were also augmented during the contraction. Results suggests that AMPA-receptors within the RVLM and CVLM differentially modulate cardiovascular responses during static muscle contraction via increasing and decreasing, respectively, extracellular glutamate concentrations. (C) 1999 Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 20:34:28