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Titolo:
An in vitro electrophysiological and Co2+-uptake study on the effect of infraorbital nerve transection on the cortical and thalamic neuronal activity
Autore:
Vilagi, I; Doczi, J; Kirilly, D; Banczerowski-Pelyhe, I; Takacs, J;
Indirizzi:
Lorand Eotvos Univ, Dept Physiol & Neurobiol, H-1088 Budapest, Hungary Lorand Eotvos Univ Budapest Hungary H-1088 iol, H-1088 Budapest, Hungary HAS, United Res Org, Neurobiol Res Grp, H-1094 Budapest, Hungary HAS Budapest Hungary H-1094 Neurobiol Res Grp, H-1094 Budapest, Hungary Semmelweis Univ Med, Dept Anat, H-1094 Budapest, Hungary Semmelweis Univ Med Budapest Hungary H-1094 at, H-1094 Budapest, Hungary
Titolo Testata:
BRAIN RESEARCH
fascicolo: 1-2, volume: 844, anno: 1999,
pagine: 118 - 125
SICI:
0006-8993(19991009)844:1-2<118:AIVEAC>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUTAMATE-RECEPTOR CHANNELS; AMINO-ACID RECEPTORS; MOUSE BARREL CORTEX; NON-NMDA RECEPTORS; CA2+ PERMEABILITY; SYNAPTIC PLASTICITY; NEONATAL LESION; RESPONSES; CIRCUITS; BRAIN;
Keywords:
barrel cortex; ventrobasal thalamus; AMPA/KAIN receptor; Co2+-staining; intracellular microelectrophysiology;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Vilagi, I Lorand Eotvos Univ, Dept Physiol & Neurobiol, Muzeum Krt 4-A, H-1088 Budapest, Hungary Lorand Eotvos Univ Muzeum Krt 4-A Budapest Hungary H-1088 ngary
Citazione:
I. Vilagi et al., "An in vitro electrophysiological and Co2+-uptake study on the effect of infraorbital nerve transection on the cortical and thalamic neuronal activity", BRAIN RES, 844(1-2), 1999, pp. 118-125

Abstract

Changes of neuronal membrane characteristics in somatosensory barrel cortex and barreloid thalamus were investigated in rats following unilateral transection of the infraorbital nerve. Kainate induced Co2+-uptake method and image analysis were used to assess the Ca2+ permeability of non-NMDA (N-methyl-D-aspartate) glutamate receptors. Changes in some biophysical parameters of the affected cortical neurons were also investigated by intracellular recording in slice experiments. The altered neuronal activity was measured on days 1, 5 and 14 after surgery. Kainate induced Co2+ uptake increased markedly reflecting enhanced Ca2+ permeability of alpha-amino-3-hydroxy-5-methyl-isoxazole-4-propionate/kainate (AMPA/KAIN)-type receptors. Changes weremore pronounced in the cortex than in the thalamus and peaked on the firstday following nerve transection. After that, parameters gradually returnedto the normal level. However, a small enhancement was still detectable in the cortex at the end of the 2-week-long observation period. In parallel with the increased Co2+-uptake, moderate membrane potential changes, strongerspiking activity and enhanced excitability were characteristic for cortical neurons. The observed alterations in neuronal characteristics underlie the reorganization and regeneration processes following injuries or surgeries. We can conclude that immediate change of the receptive field in the barrel cortex following unilateral nerve transection is based on changes in biophysical parameters of the neurons. Altered peripheral activation evokes changes in the neuronal activity, thus providing opportunity for a quick synaptic rearrangement. AMPA/KAIN-type glutamate receptors have a decisive role in the regulation of these processes. This kind of synaptic plasticity is more significant in the cortex than in the thalamus. (C) 1999 Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/04/20 alle ore 23:12:19