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Titolo:
Memantine does not substantially affect brain stimulation reward: comparison with MK-801
Autore:
Tzschentke, TM; Schmidt, WJ;
Indirizzi:
Univ Tubingen, Inst Zool, Dept Neuropharmacol, D-72074 Tubingen, Germany Univ Tubingen Tubingen Germany D-72074 rmacol, D-72074 Tubingen, Germany
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 845, anno: 1999,
pagine: 192 - 198
SICI:
0006-8993(19991023)845:2<192:MDNSAB>2.0.ZU;2-D
Fonte:
ISI
Lingua:
ENG
Soggetto:
DISCRIMINATIVE STIMULUS PROPERTIES; CONDITIONED PLACE PREFERENCE; RECEPTOR ANTAGONIST; PHENCYCLIDINE-LIKE; MORPHINE; RATS; NEURONS; CORTEX;
Keywords:
intracranial self-stimulation (ICSS); memantine; MK-801 (dizocilpine); reward; lateral hypothalamus; median forebrain bundle; curve-shift paradigm; NMDA receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
31
Recensione:
Indirizzi per estratti:
Indirizzo: Tzschentke, TM Dept Pharmacol Res & Dev, Postfach 500444, D-52088 Aachen, Germany Dept Pharmacol Res & Dev Postfach 500444 Aachen Germany D-52088
Citazione:
T.M. Tzschentke e W.J. Schmidt, "Memantine does not substantially affect brain stimulation reward: comparison with MK-801", BRAIN RES, 845(2), 1999, pp. 192-198

Abstract

The non-competitive N-methyl-D-aspartate (NMDA)-receptor antagonist MK-801(dizocilpine) has been shown to potentiate brain stimulation reward (BSR). Memantine (1-amino-3,5-dimethyladamantane) also binds to the PCP binding site of the NMDA receptor but with markedly different kinetics and affinity than MK-801. Here, we examined the effects of memantine on BSR and comparedits effects to those of MK-801. MK-801 (0.05 mg/kg-0.4 mg/kg) produced clear, dose-dependent decreases in threshold frequency, manifest in clear leftward shifts of the function relating stimulation frequency to response rate. Memantine (1 mg/kg-17.5 mg/kg) had only small effects on threshold frequencies and only at high doses, manifest in only small shifts in the frequency-response function. The highest dose of each drug also produced a decreasein maximum response rate. This study shows that memantine failed to substantially influence BSR at low to intermediate doses, suggesting that this substance is Likely to be largely devoid of rewarding effects in a therapeutic dose range. (C) 1999 Elsevier Science B.V. All rights reserved.

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Documento generato il 30/11/20 alle ore 02:12:28