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Titolo:
Study of mechanisms of calcitonin analgesia in mice - Involvement of 5-HT3receptors
Autore:
Ormazabal, MJ; Goicoechea, C; Alfaro, MJ; Sanchez, E; Martin, MI;
Indirizzi:
Univ Complutense Madrid, Fac Med, Dept Farmacol, E-28040 Madrid, Spain Univ Complutense Madrid Madrid Spain E-28040 acol, E-28040 Madrid, Spain
Titolo Testata:
BRAIN RESEARCH
fascicolo: 2, volume: 845, anno: 1999,
pagine: 130 - 138
SICI:
0006-8993(19991023)845:2<130:SOMOCA>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL SEROTONERGIC PATHWAYS; SALMON-CALCITONIN; RAT; ANTAGONISTS; PAIN; 5-HYDROXYTRYPTAMINE; ANTINOCICEPTION; BRAIN; MODULATION; AGONISTS;
Keywords:
analgesia; calcitonin; serotonin; 5-HT receptor; writhing test; mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
34
Recensione:
Indirizzi per estratti:
Indirizzo: Martin, MI Univ Complutense Madrid, Fac Med, Dept Farmacol, E-28040 Madrid, Spain Univ Complutense Madrid Madrid Spain E-28040 40 Madrid, Spain
Citazione:
M.J. Ormazabal et al., "Study of mechanisms of calcitonin analgesia in mice - Involvement of 5-HT3receptors", BRAIN RES, 845(2), 1999, pp. 130-138

Abstract

The analgesic effect of calcitonin when serotonin (5-HT) concentration is increased and the involvement of some 5-HT receptors were studied using thewrithing test in mice. 5-hydroxytryptophan (5-HTP) administration increased both 5-HT levels in the central nervous system (CNS) and calcitonin analgesia. The 5-HT1A agonist (+/-)-8-hydroxy-2-dipropylaminotetralin hydrobromide (8-OH-DPAT) diminished calcitonin analgesia, this effect being antagonised by the 5-HT1A antagonist (WAY 100, 135). As the stimulation of 5-HT1A autoreceptors reduces the turnover of 5-HT, the effect of 8-OH-DPAT on calcitonin analgesia may be attributed to this decrease. The 5-HT2A-2C agonist (+/-)-1-(4-iodo-2,5-dimethoxyphenyl)-2-aminopropane hydrochloride (DOI) diminished calcitonin analgesia. A subanalgesic dose of the 5-HT2A antagonist ketanserin failed to prevent this effect. The 5-HT3 agonist (+/-)-2-methyl-5-hydroxytryptamine maleate (2-methyl-5-HT) potentiated calcitonin analgesia,whereas it was significantly reduced by the 5-HT3 antagonist tropisetron. The effect of 2-methyl-5-HT on calcitonin analgesia was also reversed by tropisetron, This result suggests that the 5-HT3 receptor may play an important role in the relationship between calcitonin and the serotonergic system. Tropisetron also reversed the analgesia induced by calcitonin plus 5-HTP corroborating importance of the 5-HT3 receptors. (C) 1999 Elsevier Science B. V. All rights reserved.

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Documento generato il 07/07/20 alle ore 12:19:57