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Titolo:
Enantioselective troger's base synthetic receptors
Autore:
Adbo, K; Andersson, HS; Ankarloo, J; Karlsson, JG; Norell, MC; Olofsson, L; Svenson, J; Ortegren, U; Nicholls, A;
Indirizzi:
Univ Kalmar, Bioorgan Chem Lab, Inst Nat Sci, S-39129 Kalmar, Sweden Univ Kalmar Kalmar Sweden S-39129 , Inst Nat Sci, S-39129 Kalmar, Sweden
Titolo Testata:
BIOORGANIC CHEMISTRY
fascicolo: 5, volume: 27, anno: 1999,
pagine: 363 - 371
SICI:
0045-2068(199910)27:5<363:ETBSR>2.0.ZU;2-J
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOLECULARLY IMPRINTED POLYMERS; RECOGNITION; MIMICS; DESIGN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Physical, Chemical & Earth Sciences
Citazioni:
25
Recensione:
Indirizzi per estratti:
Indirizzo: Nicholls, A Univ Kalmar, Bioorgan Chem Lab, Inst Nat Sci, Box 905, S-39129Kalmar, Sweden Univ Kalmar Box 905 Kalmar Sweden S-39129 9129 Kalmar, Sweden
Citazione:
K. Adbo et al., "Enantioselective troger's base synthetic receptors", BIOORG CHEM, 27(5), 1999, pp. 363-371

Abstract

Synthetic receptors selective for the enantiomers of Troger's base (1), a compound containing chiral nitrogen atoms, have been prepared by the molecular imprinting of 1 in methacrylic acid-ethylene glycol dimethacrylate copolymers. Spectroscopic evaluation of the self-assembly phase, prior to polymerization, demonstrated the formation of template-functional monomer adducts of K-diss 0.7 +/- 0.1 mM at 293 K in chloroform. The synthetic receptors demonstrated enantioselectivity when used as HPLC chiral stationary phases;enantioseparation factors (alpha) of up to 4.8 +/- 0.2 are reported. Baseline resolution of racemic 1 was readily achieved. Furthermore, the influence of water on polymer-ligand selectivity was examined, which yielded insights into the molecular basis for ligand selectivity in these synthetic receptors. (C) 1999 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 23:17:29