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Titolo:
Cholesterol-lowering activity of naringenin via inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase and acyl coenzyme A : cholesterol acyltransferase in rats
Autore:
Lee, SH; Park, YB; Bae, KH; Bok, SH; Kwon, YK; Lee, ES; Choi, MS;
Indirizzi:
Kyungpook Natl Univ, Dept Nutr & Food Sci, Taegu 702701, South Korea Kyungpook Natl Univ Taegu South Korea 702701 , Taegu 702701, South Korea Kyungpook Natl Univ, Dept Genet Engn, Taegu 702701, South Korea Kyungpook Natl Univ Taegu South Korea 702701 , Taegu 702701, South Korea Chungnam Natl Univ, Sch Pharm, Taejon, South Korea Chungnam Natl Univ Taejon South Korea v, Sch Pharm, Taejon, South Korea KIST, Korea Inst Biosci & Biotechnol, Taejon, South Korea KIST Taejon South Korea a Inst Biosci & Biotechnol, Taejon, South Korea
Titolo Testata:
ANNALS OF NUTRITION AND METABOLISM
fascicolo: 3, volume: 43, anno: 1999,
pagine: 173 - 180
SICI:
0250-6807(199905/06)43:3<173:CAONVI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; HMG-COA REDUCTASE; SERUM-CHOLESTEROL; HYPOCHOLESTEROLEMIC ACTIVITY; METABOLISM; ABSORPTION; LIVER; INVIVO; ACAT; ESTERIFICATION;
Keywords:
high-cholesterol diet; naringenin; 3-hydroxy-3-methylglutaryl-coenzyme A reductase; acyl coenzyme A : cholesterol; O-acyltransferase; liver cholesterol; plasma cholesterol;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
47
Recensione:
Indirizzi per estratti:
Indirizzo: Choi, MS Kyungpook Natl Univ, Dept Nutr & Food Sci, Taegu 702701, South Korea Kyungpook Natl Univ Taegu South Korea 702701 02701, South Korea
Citazione:
S.H. Lee et al., "Cholesterol-lowering activity of naringenin via inhibition of 3-hydroxy-3-methylglutaryl coenzyme A reductase and acyl coenzyme A : cholesterol acyltransferase in rats", ANN NUTR M, 43(3), 1999, pp. 173-180

Abstract

The effects of dietary supplementation of a citrus bioflavonoid, naringenin, on the cholesterol metabolism were studied. For 42 days male rats were fed a 1% (wt/wt) high-cholesterol diet with or without a naringenin supplementation (0.1%, wt/wt) to study its effect on plasma lipid levels, hepatic lipid contents, activities of hepatic acyl coenzyme A:cholesterol O-acyltransferase (ACAT) and 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, and the excretion of fecal neutral sterols. Naringenin did not significantly alter the concentration of plasma triglycerides, but lowered the plasma cholesterol (3.80 vs. 3.12 mmol/l) concentration and the hepatic cholesterol content (70.3 vs. 54.0 mg/g) significantly (p < 0.05) compared to thoseof the controls. HMG-CoA reductase (1,879.0 vs. 1,715.0 pmol/min/mg) and ACAT activities (806.0 vs. 563.0 pmol/min/mg) were significantly lower in the naringenin-supplemented group than in controls. Naringenin supplementation caused a marked decrease ire the excretion of fecal neutral sterols (242.9 mg/day) compared to the controls (521.9 mg/day). These results show that naringenin lowers the plasma and hepatic cholesterol concentrations by suppressing HMG-CoA reductase and ACAT in rats fed a high-cholesterol diet.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 03:59:01