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Titolo:
Racial differences in prevalence of cobalamin and folate deficiencies in disabled elderly women
Autore:
Stabler, SP; Allen, RH; Fried, LP; Pahor, M; Kittner, SJ; Penninx, BWJH; Guralnik, JM;
Indirizzi:
Univ Colorado, Hlth Sci Ctr, Dept Med, Div Hematol, Denver, CO 80220 USA Univ Colorado Denver CO USA 80220 Med, Div Hematol, Denver, CO 80220 USA Johns Hopkins Med Inst, Dept Med, Div Geriatr, Baltimore, MD 21205 USA Johns Hopkins Med Inst Baltimore MD USA 21205 tr, Baltimore, MD 21205 USA Johns Hopkins Med Inst, Dept Epidemiol, Div Geriatr, Baltimore, MD 21205 USA Johns Hopkins Med Inst Baltimore MD USA 21205 tr, Baltimore, MD 21205 USA Univ Tennessee, Dept Prevent Med, Memphis, TN USA Univ Tennessee Memphis TN USA nnessee, Dept Prevent Med, Memphis, TN USA Univ Maryland, Sch Med, Dept Neurol, Baltimore, MD 21201 USA Univ Maryland Baltimore MD USA 21201 Dept Neurol, Baltimore, MD 21201 USA NIA, Epidemiol Demog & Biometry Program, Bethesda, MD 20892 USA NIA Bethesda MD USA 20892 emog & Biometry Program, Bethesda, MD 20892 USA
Titolo Testata:
AMERICAN JOURNAL OF CLINICAL NUTRITION
fascicolo: 5, volume: 70, anno: 1999,
pagine: 911 - 919
SICI:
0002-9165(199911)70:5<911:RDIPOC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHROMATOGRAPHY MASS-SPECTROMETRY; URINARY METHYLMALONIC ACID; CORONARY HEART-DISEASE; PLASMA HOMOCYSTEINE; VITAMIN-B12 DEFICIENCY; PERNICIOUS-ANEMIA; SERUM; DIAGNOSIS; PEOPLE; ASSAY;
Keywords:
race; methylmalonic acid; homocysteine; cobalamin; folate; women; elderly; multivitamin use;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Stabler, SP Univ Colorado, Hlth Sci Ctr, Dept Med, Div Hematol, 4200 E 9thAve,Box B-170, Denver, CO 80220 USA Univ Colorado 4200 E 9th Ave,Box B-170Denver CO USA 80220 USA
Citazione:
S.P. Stabler et al., "Racial differences in prevalence of cobalamin and folate deficiencies in disabled elderly women", AM J CLIN N, 70(5), 1999, pp. 911-919

Abstract

Background: Many previous investigations of cobalamin and folate status were performed in white populations. Objective: Our objective was to determine whether there are racial differences in the prevalence of cobalamin and folate deficiency. Design: The study was a cross-sectional comparison of baseline serum cobalamin, folate, methylmalonic acid (MMA), total homocysteine (tHcy), and creatinine concentrations, complete blood count, and vitamin supplementation in550 white and 212 African American subjects from a cohort of physically disabled older women. Results: The mean (ISD) serum MMA concentration was significantly higher in whites than in African Americans: 284 +/- 229 compared with 218 +/- 158 nmol/L (P = 0.0001), tHcy concentration was higher in African Americans thanin whites: 12.4 +/- 7.0 compared with 10.9 +/- 4.6 mu mol/L (P = 0.001). Serum cobalamin was lower in whites (P = 0.0002). Cobalamin deficiency (serum cobalamin <258 mu mol/L and MMA >271 nmol/L) was more frequent in the white women (19% compared with 8%; P < 0.0003). Folate deficiency (serum folate <11.4 nmol/L, tHcy >13.9 mu mol/L, and MMA <271 nmol/L) was more prevalent in African Americans than in whites (5% compared with 2%; P = 0.01). Multivitamin use was associated with lower tHcy but not with MMA concentrations. Regression models showed that age >85 y, African American race, serum creatinine >90 mu mol/L, and high MMA concentration were all significantly correlated with higher tHcy, Creatinine > 90 mu mol/L, white race, and folate concentration were positively associated with MMA concentration. Conclusions: Cobalamin deficiency with elevated serum MMA concentration ismore prevalent in elderly white than in African American women and elevated serum tHcy and folate deficiency are more prevalent in elderly African American than in white women.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 10:00:28