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Titolo:
THYMOSIN ALPHA(1) ANTAGONIZES DEXAMETHASONE AND CD3-INDUCED APOPTOSISOF CD4(-KINASE-C DEPENDENT 2ND-MESSENGER PATHWAYS()CD8(+) THYMOCYTES THROUGH THE ACTIVATION OF CAMP AND PROTEIN)
Autore:
BAUMANN CA; BADAMCHIAN M; GOLDSTEIN AL;
Indirizzi:
GEORGE WASHINGTON UNIV,SCH MED & HLTH SCI,DEPT BIOCHEM & MOL BIOL,2300 EYE ST NW WASHINGTON DC 20037 GEORGE WASHINGTON UNIV,SCH MED & HLTH SCI,DEPT BIOCHEM & MOL BIOL WASHINGTON DC 20037
Titolo Testata:
Mechanism of ageing and development
fascicolo: 1-3, volume: 94, anno: 1997,
pagine: 85 - 101
SICI:
0047-6374(1997)94:1-3<85:TAADAC>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
ENDOGENOUS ENDONUCLEASE ACTIVATION; PROGRAMMED CELL-DEATH; NEGATIVE SELECTION; POSITIVE SELECTION; OXIDATIVE STRESS; FLOW-CYTOMETRY; IN-SITU; THYMUS; LYMPHOCYTES; EXPRESSION;
Keywords:
THYMUS; THYMOSIN ALPHA(1); THYMOCYTE; APOPTOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
C.A. Baumann et al., "THYMOSIN ALPHA(1) ANTAGONIZES DEXAMETHASONE AND CD3-INDUCED APOPTOSISOF CD4(-KINASE-C DEPENDENT 2ND-MESSENGER PATHWAYS()CD8(+) THYMOCYTES THROUGH THE ACTIVATION OF CAMP AND PROTEIN)", Mechanism of ageing and development, 94(1-3), 1997, pp. 85-101

Abstract

It is well established that glucocorticoid hormones and anti-CD3 monoclonal antibodies induce apoptosis in immature developing thymocytes. This process can be modulated by soluble factors, anti-oxidants and adhesion receptors. Previously we have demonstrated that thymosin alpha(1) (T alpha(1)), a 28-amino acid thymic peptide hormone, is a dose andtime dependent antagonist of dexamethasone (DEX) and CD3 induced DNA.fragmentation of murine thymocytes in vitro. To further investigate the mechanism of T alpha(1) action we determined a T alpha(1) sensitivethymocyte population and examined same of the molecular events associated with T alpha(1) anti-apoptotic activity. Phenotypic analysis of the sub-populations of thymocytes, based on CD4 and CD8 expression, revealed that T alpha(1) exerts its effect on CD4(+) CD8(+) immature thymocytes. T alpha(1) treatment of thymocytes delays the production of free radicals and the subsequent consumption of glutathione, that is observed during both DEX and CD3 induced apoptosis. We further demonstrate that T alpha(1) stimulates the production of cAMP and activates PKC in thymocytes. These data suggest that T alpha(1) exerts an influence on the development of a population of immature T-cells in the thymus by effecting the sensitivity of thymocytes to apoptosis during the pre-selection stages of thymic development. Our studies also suggest that the mechanism of T alpha(1) action involves the induction of both cAMPand PKC dependent second messenger pathways. (C) 1997 Elsevier Science Ireland Ltd.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/09/20 alle ore 00:08:50