Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Tyrosine transport is regulated differently in patients with schizophrenia
Autore:
Wiesel, FA; Andersson, JLR; Westerberg, G; Wieselgren, IM; Bjerkenstedt, L; Hagenfeldt, L; Langstrom, B;
Indirizzi:
Univ Uppsala Hosp, Dept Neurosci, S-75017 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden S-75017 urosci, S-75017 Uppsala, Sweden Univ Uppsala, PET Ctr, S-75185 Uppsala, Sweden Univ Uppsala Uppsala Sweden S-75185 la, PET Ctr, S-75185 Uppsala, Sweden Japan Sci Technol Corp, Subfemtomole Biorecognit Project, S-75185 Uppsala,Sweden Japan Sci Technol Corp Uppsala Sweden S-75185 ct, S-75185 Uppsala,Sweden Ostermalm Lidingo, Dept Psychiat, S-11449 Stockholm, Sweden Ostermalm Lidingo Stockholm Sweden S-11449 at, S-11449 Stockholm, Sweden Huddinge Hosp, Dept Clin Chem, S-14186 Huddinge, Sweden Huddinge Hosp Huddinge Sweden S-14186 lin Chem, S-14186 Huddinge, Sweden
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 1, volume: 40, anno: 1999,
pagine: 37 - 42
SICI:
0920-9964(19991109)40:1<37:TTIRDI>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
FATTY-ACID COMPOSITION; FIBROBLASTS; BRAIN;
Keywords:
amino acid; normals; positron emission tomography; schizophrenia; transport kinetics; tyrosine;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
15
Recensione:
Indirizzi per estratti:
Indirizzo: Wiesel, FA Univ Uppsala Hosp, Dept Neurosci, S-75017 Uppsala, Sweden Univ Uppsala Hosp Uppsala Sweden S-75017 5017 Uppsala, Sweden
Citazione:
F.A. Wiesel et al., "Tyrosine transport is regulated differently in patients with schizophrenia", SCHIZOPHR R, 40(1), 1999, pp. 37-42

Abstract

Previous PET studies of tyrosine transport have suggested that the transport of tyrosine from blood to brain compartment is not dependent on its plasma concentration in patients with schizophrenia. In order to examine this relationship, the transport constant (K-1) of tyrosine was determined in five patients with schizophrenia and five normals. L-[1-C-11]Tyrosine was injected i.v. and arterial blood samples were taken during PET scanning. The tyrosine transport was assessed during baseline conditions and after oral administration of L-tyrosine at a dose (175 mg/kg) that significantly elevated the plasma levels. K-1 was determined from tracer kinetic modelling. The transport rate dropped in the normals after tyrosine loading, which isconsistent with the prevailing notion that the brain transport system for neutral amino acids works close to saturation, whereas it was virtually unchanged in the schizophrenics. The results demonstrated that tyrosine transport was not saturated in the patients with schizophrenia and thus could lead to elevated brain concentrations of tyrosine. (C) 1999 Elsevier Science B. V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/01/21 alle ore 15:31:18