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Titolo:
Association between a promoter polymorphism in the dopamine D2 receptor gene and schizophrenia
Autore:
Jonsson, EG; Nothen, MM; Neidt, H; Forslund, K; Rylander, G; Mattila-Evenden, M; Asberg, M; Propping, P; Sedvall, GC;
Indirizzi:
Karolinska Inst, Dept Clin Neurosci, Psychiat Sect, SE-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden SE-17176 ct, SE-17176 Stockholm, Sweden Univ Bonn, Inst Human Genet, D-5300 Bonn, Germany Univ Bonn Bonn GermanyD-5300 nn, Inst Human Genet, D-5300 Bonn, Germany
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 1, volume: 40, anno: 1999,
pagine: 31 - 36
SICI:
0920-9964(19991109)40:1<31:ABAPPI>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSITRON EMISSION TOMOGRAPHY; -141C INS/DEL; ALLELES; LINKAGE; REGION; BRAIN; ALCOHOLISM; VARIANT; LOCI;
Keywords:
association; genetics; dopamine D2 receptor gene locus; dopamine receptor; schizophrenia;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Jonsson, EG Karolinska Inst, Dept Clin Neurosci, Psychiat Sect, SE-17176 Stockholm, Sweden Karolinska Inst Stockholm Sweden SE-17176 Stockholm, Sweden
Citazione:
E.G. Jonsson et al., "Association between a promoter polymorphism in the dopamine D2 receptor gene and schizophrenia", SCHIZOPHR R, 40(1), 1999, pp. 31-36

Abstract

Genetic factors and dopamine receptor dysfunction have been implicated in the pathophysiology of schizophrenia. Recently, an association between a putative functional promoter polymorphism (-141C Ins/Del) in the dopamine D2 receptor gene and schizophrenia was reported. We investigated unrelated Swedish schizophrenic patients (n=129) and control subjects (n=179) for the same polymorphism. Similarly to a previous Japanese report, the -141C Del allele frequency was significantly lower in patients than controls (chi(2)=4.4, 1 df, p<0.05; odds ratio 0.49, 95% confidence interval 0.26-0.91). The present and previous results may indicate that the -141C Ins/Del dopamine D2 receptor gene polymorphism affects susceptibility to schizophrenia. (C) 1999 Elsevier Science B.V. All rights reserved.

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Documento generato il 26/01/20 alle ore 00:43:48