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Titolo:
Ventriculomegaly and reduced hippocampal volume following intrauterine growth-restriction: implications for the aetiology of schizophrenia
Autore:
Mallard, EC; Rehn, A; Rees, S; Tolcos, M; Copolov, D;
Indirizzi:
Univ Melbourne, Dept Cell Biol & Anat, Parkville, Vic 3052, Australia UnivMelbourne Parkville Vic Australia 3052 arkville, Vic 3052, Australia Mental Hlth Res Inst, Parkville, Vic 3052, Australia Mental Hlth Res InstParkville Vic Australia 3052 le, Vic 3052, Australia
Titolo Testata:
SCHIZOPHRENIA RESEARCH
fascicolo: 1, volume: 40, anno: 1999,
pagine: 11 - 21
SICI:
0920-9964(19991109)40:1<11:VARHVF>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
FETAL GUINEA-PIG; ANTERIOR CINGULATE CORTEX; HYPOXIC-ISCHEMIC INJURY; PRENATAL EXPOSURE; DOPAMINE TRANSPORTER; CORTICAL DEVELOPMENT; ADULT SCHIZOPHRENIA; INFLUENZA EPIDEMIC; HEAD CIRCUMFERENCE; THYROID-HORMONE;
Keywords:
brain development; dopamine transporter (DAT); immunohistochemistry; neuronal nitric oxide synthase (nNOS); placental insufficiency; tyrosine hydroxylase (TH);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
61
Recensione:
Indirizzi per estratti:
Indirizzo: Rees, S Univ Melbourne, Dept Cell Biol & Anat, Parkville, Vic 3052, Australia Univ Melbourne Parkville Vic Australia 3052 , Vic 3052, Australia
Citazione:
E.C. Mallard et al., "Ventriculomegaly and reduced hippocampal volume following intrauterine growth-restriction: implications for the aetiology of schizophrenia", SCHIZOPHR R, 40(1), 1999, pp. 11-21

Abstract

Structural alterations in the brains of some schizophrenic patients suggest an impairment of brain development, possibly as a result of intrauterine compromise. In this study we have tested the hypothesis that placental insufficiency during the second half of pregnancy in the guinea pig results in structural alterations similar to those seen in some schizophrenic patients. Placental insufficiency was induced in pregnant guinea pigs via uterine artery ligation at midgestation. At 60 days gestation (term: 68 days gestation) the fetal brains were prepared for quantitative histological and immunohistochemical analysis and compared with controls. Placental insufficiency resulted in growth-restricted animals with significantly larger cerebral ventricles, reduced cross-sectional area of the cerebral cortex and the striatum and reduced hippocampal volume compared with controls. There were fewerneuronal nitric oxide synthase (nNOS)-positive cells in layers 5-6 of the cingulate cortex, and in layer 1 of the frontal and temporal cortices. In contrast, there were no significant alterations in the optical density of tyrosine hydroxylase (TH), a rate-limiting enzyme in the biosynthesis of catecholamines and the dopamine transporter (DAT) in the striatum in growth-restricted animals compared with controls. These findings indicate that developmental disturbances can produce anatomical changes that resemble those found in some individuals with schizophrenia. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 08:18:08