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Titolo:
Elevated interleukin-6 in schizophrenia
Autore:
van Kammen, DP; McAllister-Sistilli, CG; Kelley, ME; Gurklis, JA; Yao, JK;
Indirizzi:
VA Pittsburgh Healthcare Syst, Pittsburgh, PA 15240 USA VA Pittsburgh Healthcare Syst Pittsburgh PA USA 15240 burgh, PA 15240 USA Univ Pittsburgh, Sch Med, Dept Psychiat, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 sychiat, Pittsburgh, PA 15260 USA Univ Pittsburgh, Sch Med, Dept Pathol, Pittsburgh, PA 15260 USA Univ Pittsburgh Pittsburgh PA USA 15260 Pathol, Pittsburgh, PA 15260 USA
Titolo Testata:
PSYCHIATRY RESEARCH
fascicolo: 2-3, volume: 87, anno: 1999,
pagine: 129 - 136
SICI:
0165-1781(19991011)87:2-3<129:EIIS>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVOUS-SYSTEM INVOLVEMENT; STIMULATORY FACTOR-II; CEREBROSPINAL-FLUID; PLASMA-LEVELS; HALOPERIDOL WITHDRAWAL; RHEUMATOID-ARTHRITIS; SERUM INTERLEUKIN-6; CYTOKINE LEVELS; HUMAN BLOOD; IL-6;
Keywords:
schizophrenia; serum; CSF; interleukin-6;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social & Behavioral Sciences
Life Sciences
Citazioni:
51
Recensione:
Indirizzi per estratti:
Indirizzo: van Kammen, DP RW Johnson Pharmaceut Res Inst, 920 Route 202,POB 300, Raritan, NJ 08869 USA RW Johnson Pharmaceut Res Inst 920 Route 202,POB 300 Raritan NJ USA 08869
Citazione:
D.P. van Kammen et al., "Elevated interleukin-6 in schizophrenia", PSYCHIAT R, 87(2-3), 1999, pp. 129-136

Abstract

Interleukin 6 (IL-6) levels have been shown to be increased in a number ofautoimmune disorders and have recently been shown to be elevated in the serum of schizophrenic patients. Given the involvement of the CNS in schizophrenia, levels of interleukin-6 in the CSF are also of interest. Thus, we examined levels of both CSF and serum IL-6 concomitantly to determine if these levels were different from control values. In addition, we examined thesemeasures in patients both on and off antipsychotic drugs to determine if any medication or exacerbation effects may account for the difference from controls. CSF IL-6 was measured by ELISA in 61 drug-free male schizophrenic (DSM-IIIR) patients and 25 well-screened healthy male control subjects. Serum IL-6 was measured in 43 of the 61 patients, and in 16 control subjects. Serum IL-6 was significantly higher in the schizophrenic patients compared to control subjects. CSF IL-6 was also higher in the patients, but the difference was not statistically significant. Paired data showed no medication or exacerbation effects on CSF IL-6, but plasma IL-6 significantly decreased in patients that experienced an exacerbation after medication withdrawal. The results indicate that IL-6 levels may be altered in schizophrenia. Therelative decrease in exacerbated patients following haloperidol withdrawalmay be indicative of a compensatory response of plasma IL-6 levels to relapse. (C) 1999 Published by Elsevier Science Ireland Ltd. All rights reserved.

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Documento generato il 03/04/20 alle ore 03:15:31