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Titolo:
Acute inflammation of the proliferative zone of gastric mucosa in Helicobacter pylori gastritis
Autore:
Yu, E; Lee, HK; Kim, HR; Lee, MS; Lee, I;
Indirizzi:
Univ Ulsan, Coll Med, Dept Pathol, Asan Med Ctr, Seoul, South Korea Univ Ulsan Seoul South Korea t Pathol, Asan Med Ctr, Seoul, South Korea Univ Ulsan, Coll Med, Dept Internal Med, Asan Med Ctr, Seoul, South Korea Univ Ulsan Seoul South Korea rnal Med, Asan Med Ctr, Seoul, South Korea Univ Ulsan, Coll Med, Dept Prevent Med, Asan Med Ctr, Seoul, South Korea Univ Ulsan Seoul South Korea vent Med, Asan Med Ctr, Seoul, South Korea
Titolo Testata:
PATHOLOGY RESEARCH AND PRACTICE
fascicolo: 10, volume: 195, anno: 1999,
pagine: 689 - 697
SICI:
0344-0338(1999)195:10<689:AIOTPZ>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAMPYLOBACTER-PYLORI; SYDNEY SYSTEM; INFECTION; INTERLEUKIN-8;
Keywords:
H. pylori gastritis; acute epithelial inflammation; proliferative zone;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
23
Recensione:
Indirizzi per estratti:
Indirizzo: Lee, I Dept Ulsan Coll Med, Songpa Gu, 388-1 Poongnap Dong, Seoul 138736, South Korea Dept Ulsan Coll Med 388-1 Poongnap Dong Seoul South Korea 138736 a
Citazione:
E. Yu et al., "Acute inflammation of the proliferative zone of gastric mucosa in Helicobacter pylori gastritis", PATH RES PR, 195(10), 1999, pp. 689-697

Abstract

The neutrophilic infiltration has been regarded to represent the activity of Helicobacter pylori gastritis. It may involve the epithelium and/or lamina propria. The incidence and degree of the two types of infiltration do not con elate with each other frequently. We correlated the two types of neutrophilic infiltration with H. pylori infection and other pathologic parameters respectively in 300 randomly selected gastric biopsies as well as serial biopsies from a separate group of 95 patients who were treated for H, pylori infection. The "random biopsies" had chronic gastritis of various degrees, and the organisms were identified in 239 cases (79.7%); in the "treatedgroup," the organisms disappeared completely in 62 cases (65.3%). Characteristically, the intraepithelial neutrophilic infiltration was predominantlylocalized to the proliferative zone of the gastric mucosa (zone 2) where the density of H. pylori was considerably lower than the surface epithelium. In the "random biopsies," both acute epithelial and interstitial neutrophilic infiltration correlated significantly (p < 0.01) with the H. pylori infection. In the "treated group," however, only acute epithelial inflammationcorrelated significantly (p < 0.01) with the eradication of infection while acute interstitial inflammation did not. Acute epithelial inflammation was no less frequently present in advanced chronic gastritis than in early chronic gastritis. Acute epithelial inflammation of the proliferative zone isa characteristic pathologic finding of H. pylori gastritis, and appears tobe directly associated with the pathogenesis of H. pylori gastritis and its progression.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 01:39:53