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Titolo:
Effects of an anti-angiogenic agent, TNP-470, on the growth of oral squamous cell carcinomas
Autore:
Ueda, N; Kamata, N; Hayashi, E; Yokoyama, K; Hoteiya, T; Nagayama, M;
Indirizzi:
Univ Tokushima, Sch Dent, Dept Oral & Maxillofacial Surg 1, Tokushima 7708504, Japan Univ Tokushima Tokushima Japan 7708504 Surg 1, Tokushima 7708504, Japan
Titolo Testata:
ORAL ONCOLOGY
fascicolo: 6, volume: 35, anno: 1999,
pagine: 554 - 560
SICI:
1368-8375(199911)35:6<554:EOAAAT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
INHIBITOR TNP-470; TUMOR-GROWTH; AGM-1470; METASTASIS; FUMAGILLIN; CANCER; SUPPRESSION; EXPRESSION; BREAST; LINES;
Keywords:
anti-angiogenic agent; TNP-470; growth inhibition; oral squamous cell carcinomas; endothelial cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
30
Recensione:
Indirizzi per estratti:
Indirizzo: Kamata, N Univ Tokushima, Sch Dent, Dept Oral & Maxillofacial Surg 1, 3-18-15 Kuramoto Cho, Tokushima 7708504, Japan Univ Tokushima 3-18-15 Kuramoto Cho Tokushima Japan 7708504 pan
Citazione:
N. Ueda et al., "Effects of an anti-angiogenic agent, TNP-470, on the growth of oral squamous cell carcinomas", ORAL ONCOL, 35(6), 1999, pp. 554-560

Abstract

Anti-tumor effects of an anti-angiogenic agent, TNP-470, on the growth of oral squamous cell carcinomas (SCCs) were evaluated in vivo and in vitro. The growth of an oral SCC cell line, HSC-2, inoculated subcutaneously in severe combined immune-deficiency (SCID) mice was inhibited in a dose-dependent manner by the treatment with this agent. A reduction of microvessels surrounding tumor tissues treated with TNP-470 was observed by immunohistochemistry. Significant side-effects were not observed except for weight loss during the period of treatment with high dose (50 mg/kg) of TNP-470. The direct effects of TNP-470 on oral SCC cell lines were also evaluated in culture. The growth of all eight SCC cell lines tested was inhibited by TNP-470, but the sensitivity of the oral SCC cell lines to TNP-470 was about 1700 times less than that of endothelial cells. These results suggest that TNP-470 inhibits the growth of oral SCC by anti-angiogenic activities and that it may be effective as a new therapy of oral cancer. (C) 1999 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 16:10:51