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Titolo:
THE CHANGING FACE OF THE EPIDEMIOLOGY OF TUBERCULOSIS DUE TO MOLECULAR STRAIN TYPING - A REVIEW
Autore:
SUFFYS PN; DEARAUJO MEI; DEGRAVE WM;
Indirizzi:
INST OSWALDO CRUZ,DEPT BIOQUIM & BIOL MOL,LAB BIOL MOL & DIAGNOST DOENCAS INFECC,AV BRASIL 4365 BR-21045900 RIO JANEIRO BRAZIL
Titolo Testata:
Memorias do Instituto Oswaldo Cruz
fascicolo: 3, volume: 92, anno: 1997,
pagine: 297 - 316
SICI:
0074-0276(1997)92:3<297:TCFOTE>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
FRAGMENT-LENGTH-POLYMORPHISM; RESISTANT MYCOBACTERIUM-TUBERCULOSIS; HEALTH-CARE WORKERS; HUMAN-IMMUNODEFICIENCY-VIRUS; POLYMERASE CHAIN-REACTION; 16S-23S SPACER REGION; DEOXYRIBONUCLEIC-ACID RELATEDNESS; RESTRICTION ENDONUCLEASE ANALYSIS; SLOWLY-GROWING MYCOBACTERIA; SOUTHERN BLOT HYBRIDIZATION;
Keywords:
TUBERCULOSIS; MOLECULAR EPIDEMIOLOGY; FINGERPRINTING; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
136
Recensione:
Indirizzi per estratti:
Citazione:
P.N. Suffys et al., "THE CHANGING FACE OF THE EPIDEMIOLOGY OF TUBERCULOSIS DUE TO MOLECULAR STRAIN TYPING - A REVIEW", Memorias do Instituto Oswaldo Cruz, 92(3), 1997, pp. 297-316

Abstract

About one third of the world population is infected with tubercle bacilli, causing eight million new cases of tuberculosis (TB) and three million deaths each year. After years of lack of interest in the disease, World Health Organization recently declared TB a global emergency and it is clear that there is need for more efficient national TB programs and newly defined research priorities. A more complete epidemiology of tuberculosis will lead to a better identification of index cases and to a more efficient treatment of the disease. Recently, new molecular tools became available for the identification of strains of Mycobacterium tuberculosis (M. tuberculosis), allowing a better recognition of transmission routes of defined strains. Both a standardised restriction-fragment-length-polymorphism-based methodology for epidemiological studies on a large scale and deoxyribonucleic acids (DNA) amplification-based methods that allow rapid detection of outbreaks with multidrug-resistant (MDR) strains, often characterized by high mortality rates, have been developed This review comments on the existing methods ofDNA-based recognition of M. tuberculosis strains and their peculiarities. If also summarizes literature data on the application of molecular fingerprinting for detection of outbreak of M. tuberculosis, for identification of index cases, for study of interaction between TB and infection with the human immunodeficiency virus, for analysis of the behavior of MDR strains, for a better understanding of risk factors for transmission of TB within communities and for population-based studies of TB transmission within and between countries.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 04:58:41