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Titolo:
FATAL OVERDOSE OF CLOZAPINE
Autore:
KELLER T; MIKI A; BINDA S; DIRNHOFER R;
Indirizzi:
INST FORENS MED,VOSS STR 2,GEB 42 D-69115 HEIDELBERG GERMANY UNIV BERN,INST FORENS MED CH-3012 BERN SWITZERLAND OSAKA PREFECTURAL POLICE HEADQUARTERS,FORENS SCI LAB,CHUO KU OSAKA 541 JAPAN
Titolo Testata:
Forensic science international
fascicolo: 1-2, volume: 86, anno: 1997,
pagine: 119 - 125
SICI:
0379-0738(1997)86:1-2<119:FOOC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
PERFORMANCE LIQUID-CHROMATOGRAPHY; SOLID-PHASE EXTRACTION; ULTRAVIOLET DETECTION; HUMAN-SERUM; MAJOR METABOLITES; GAS-CHROMATOGRAPHY; HUMAN PLASMA; N-OXIDE; DESMETHYLCLOZAPINE; SCHIZOPHRENIA;
Keywords:
TOXICOLOGY; LEPONEX(R); CLOZAPINE; N-DESMETHYLCLOZAPINE; OVERDOSE; POISON; SUICIDE; GC/NPD;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
29
Recensione:
Indirizzi per estratti:
Citazione:
T. Keller et al., "FATAL OVERDOSE OF CLOZAPINE", Forensic science international, 86(1-2), 1997, pp. 119-125

Abstract

An ingestion of an unknown quantity of Leponex(R) (clozapine) tabletsin a suicide is described. Although clozapine is known for over 30 years now, relatively few cases of intoxications due to clozapine overdose have been reported. The authors report a new and quick method to analyze and determine the clozapine and N-desmethylclozapine concentration in body fluids. The analytes and an internal standard (zolpidem) were extracted from alkalinized samples into ethyl acetate before GC/NPDanalysis. The proposed method resulted in a rapid procedure most useful in cases of deliberate poisoning with the neuroleptic drug Leponex(R). (C) 1997 Elsevier Science Ireland Ltd.

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Documento generato il 27/01/20 alle ore 16:48:22