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Titolo:
The conditioned avoidance response test re-evaluated: is it a sensitive test for the detection of potentially atypical antipsychotics?
Autore:
Wadenberg, MLG; Hicks, PB;
Indirizzi:
Scott & White Clin, Dept Psychiat, Temple, TX 75608 USA Scott & White Clin Temple TX USA 75608 ept Psychiat, Temple, TX 75608 USA
Titolo Testata:
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
fascicolo: 6, volume: 23, anno: 1999,
pagine: 851 - 862
SICI:
0149-7634(199910)23:6<851:TCARTR>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECEPTOR ANTAGONIST; DOPAMINE-RECEPTOR; INDUCED DISRUPTION; NUCLEUS-ACCUMBENS; FREEZING BEHAVIOR; LOCAL APPLICATION; BRAIN DOPAMINE; 5-HT2 RECEPTOR; ASCORBIC-ACID; RATS;
Keywords:
conditioned avoidance response; antipsychotic drugs; brain neurotransmitter receptors; nucleus accumbens(shell); rat;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
121
Recensione:
Indirizzi per estratti:
Indirizzo: Wadenberg, MLG Ctr Addict & Mental Hlth, Clarke Div, 250 Coll St, Toronto,ON M5T 1R8, Canada Ctr Addict & Mental Hlth 250 Coll St Toronto ON Canada M5T 1R8
Citazione:
M.L.G. Wadenberg e P.B. Hicks, "The conditioned avoidance response test re-evaluated: is it a sensitive test for the detection of potentially atypical antipsychotics?", NEUROSCI B, 23(6), 1999, pp. 851-862

Abstract

The present review discusses the history and paradigm of the conditioned avoidance response (CAR) in rats for the detection of potential antipsychotic activity of drugs. In addition, the role of dopamine (DA) D-2, serotonin (5-HT)(2A/2C) alpha(1), 5-HT, DA D-4 muscarinic and glutamate receptors in the suppression of CAR induced by various classes of drugs is evaluated. Finally, data investigating brain sites of action for the mediation of CAR behavior is discussed. It is concluded that the CAR test, originally found to be sensitive for the detection of antipsychotic drugs with high affinity as antagonists for brain dopamine receptors, is also sensitive for the detection of potentially antipsychotic compounds acting primarily via neurotransmitter receptors other than the DA D-2 receptor. Furthermore, the review confirms the importance of the nucleus accumbens(shell) in the mediation of effects on CAR produced by traditional, as well as atypical antipsychotic drugs. (C) 1999 Elsevier Science Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/20 alle ore 14:00:26