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Titolo:
Ultra-slow oscillation (0.025 Hz) triggers hippocampal afterdischarges in Wistar rats
Autore:
Penttonen, M; Nurminen, N; Miettinen, R; Sirvio, J; Henze, DA; Csicsvari, J; Buzsaki, G;
Indirizzi:
Univ Kuopio, A I Virtanen Inst Mol Sci, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 Mol Sci, FIN-70211 Kuopio, Finland Univ Kuopio, Dept Neurol & Neurosci, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 Neurosci, FIN-70211 Kuopio, Finland Univ Kuopio, Kuopio Univ Hosp, FIN-70211 Kuopio, Finland Univ Kuopio Kuopio Finland FIN-70211 niv Hosp, FIN-70211 Kuopio, Finland Rutgers State Univ, Ctr Mol & Behav Neurosci, Newark, NJ 07102 USA RutgersState Univ Newark NJ USA 07102 hav Neurosci, Newark, NJ 07102 USA
Titolo Testata:
NEUROSCIENCE
fascicolo: 3, volume: 94, anno: 1999,
pagine: 735 - 743
SICI:
0306-4522(1999)94:3<735:UO(HTH>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
INHIBITORY POSTSYNAPTIC POTENTIALS; CYCLIC ALTERNATING PATTERN; IN-VITRO; SPIKE-WAVE; ELECTROPHYSIOLOGICAL PROPERTIES; EPILEPTIC AFTERDISCHARGE; FREQUENCY-OSCILLATION; RECEPTOR ACTIVATION; INTACT HIPPOCAMPUS; PYRAMIDAL NEURONS;
Keywords:
oscillation; afterdischarges; strain; inhibition; hippocampus; subiculum;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
63
Recensione:
Indirizzi per estratti:
Indirizzo: Penttonen, M Univ Kuopio, A I Virtanen Inst Mol Sci, POB 1627, FIN-70211 Kuopio, Finland Univ Kuopio POB 1627 Kuopio Finland FIN-70211 uopio, Finland
Citazione:
M. Penttonen et al., "Ultra-slow oscillation (0.025 Hz) triggers hippocampal afterdischarges in Wistar rats", NEUROSCIENC, 94(3), 1999, pp. 735-743

Abstract

Oscillations in neuronal networks are assumed to serve various physiological functions, from coordination of motor patterns to perceptual binding of sensory information. Here, we describe an ultra-slow oscillation (0.025 Hz)in the hippocampus. Extracellular and intracellular activity was recorded from the CA1 and subicular regions in rats of the Wistar and Sprague-Dawleystrains. anesthetized with urethane. in a subgroup of Wistar rats (23%), spontaneous afterdischarges (4.7 +/- 1.6 s) occurred regularly at 40.8 +/- 15.7 s. The afterdischarge was initiated by a fast increase of population synchrony (100-250 Hz oscillation; "tonic" phase), followed by large-amplitude rhythmic waves and associated action potentials at gamma and beta frequency (15-50 Hz; "clonic" phase). The afterdischarges were bilaterally synchronous and terminated relatively abruptly without post-ictal depression. Single-pulse stimulation of the commissural input could trigger afterdischarges, but only at times when they were about to occur. Commissural stimulation evoked inhibitory postsynaptic potentials in pyramidal cells. However, whenthe stimulus triggered an afterdischarge, the inhibitory postsynaptic potential was absent and the cells remained depolarized during most of the afterdischarge. Afterdischarges were not observed in the Sprague-Dawley rats. Long-term analysis of interneuronal activity in intact, drug-free rats also revealed periodic excitability changes in the hippocampal network at 0.025 Hz. These findings indicate the presence of an ultra-slow oscillation in the hippocampal formation. The ultra-slow clock induced afterdischarges in susceptible animals. We hypothesize that a transient failure of GABAergic inhibition in a subset of Wistar rats is responsible for the emergence of epileptiform patterns. (C) 1999 IBRO. Published by Elsevier Science Ltd.

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Documento generato il 22/01/20 alle ore 18:51:28