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Titolo:
Serum amyloid P is not present in amyloid beta deposits of a transgenic animal model
Autore:
Shi, J; Perry, G; Aliev, G; Smith, MA; Ashe, KH; Friedland, RP;
Indirizzi:
Case Western Reserve Univ, Sch Med, Dept Neurol, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Case Western Reserve Univ, Sch Med, Dept Pathol, Cleveland, OH 44106 USA Case Western Reserve Univ Cleveland OH USA 44106 Cleveland, OH 44106 USA Univ Minnesota, Dept Neurol, Minneapolis, MN 55455 USA Univ Minnesota Minneapolis MN USA 55455 Neurol, Minneapolis, MN 55455 USA
Titolo Testata:
NEUROREPORT
fascicolo: 15, volume: 10, anno: 1999,
pagine: 3229 - 3232
SICI:
0959-4965(19991019)10:15<3229:SAPINP>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
HEPARAN-SULFATE PROTEOGLYCAN; ALZHEIMERS-DISEASE; NEUROFIBRILLARY TANGLES; COMPONENT; PLAQUES; BINDING; ACCUMULATION; PROTEOLYSIS; VESSELS; PROTEIN;
Keywords:
Alzheimer's disease; basic fibroblastic growth factor; blood-brain barrier; serum amyloid P component;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Friedland, RP Case Western Reserve Univ, Sch Med, Dept Neurol, Room TG2A,10900 Euclid Ave, Cleveland, OH 44106 USA Case Western Reserve Univ Room TG2A,10900 Euclid Ave Cleveland OH USA 44106
Citazione:
J. Shi et al., "Serum amyloid P is not present in amyloid beta deposits of a transgenic animal model", NEUROREPORT, 10(15), 1999, pp. 3229-3232

Abstract

SERUM amyloid P component (SAP) is associated with amyloid beta (A beta) deposition in Alzheimer disease (AD). Since SAP is exclusively synthesized by peripheral organs, its presence in the brain of A beta suggests impairment of the blood-brain barrier (BBB). We studied the association of SAP with A beta deposits in a transgenic mouse model overexpressing beta-protein precursor (X PP). Both SAP and another extracellular matrix binding protein, basic fibroblastic growth factor bind to the heparinase sensitive sites of Abeta deposits in this model. However, no endogenous SAP immunoreactivity was found in the transgenic mouse brain. These results suggest that SAP is not required for A beta deposition, and that this mouse model does not develop the same BBB abnormalities as those seen in AD. (C) 1999 Lippincott Williams & Wilkins.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 09:37:25