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Titolo:
Antiplatelet therapy: Views from the experts
Autore:
Easton, JD; Diener, HC; Bornstein, NM; Einhaupl, K; Gent, M; Kaste, M; Sacco, RL; Tijssen, JGP; van Gijn, J;
Indirizzi:
Brown Univ, Sch Med, Dept Clin Neurosci, Providence, RI 02903 USA Brown Univ Providence RI USA 02903 lin Neurosci, Providence, RI 02903 USA Rhode Isl Hosp, Dept Neurol, Providence, RI 02902 USA Rhode Isl Hosp Providence RI USA 02902 t Neurol, Providence, RI 02902 USA Univ Essen Gesamthsch, Dept Neurol, Essen, Germany Univ Essen Gesamthsch Essen Germany mthsch, Dept Neurol, Essen, Germany Tel Aviv Univ, Dept Neurol, Tel Aviv Med Ctr, Sackler Fac Med, IL-69978 Tel Aviv, Israel Tel Aviv Univ Tel Aviv Israel IL-69978 ac Med, IL-69978 Tel Aviv, Israel Humboldt Univ, Hosp Charite, Dept Neurol, Berlin, Germany Humboldt Univ Berlin Germany Hosp Charite, Dept Neurol, Berlin, Germany Hamilton Civ Hosp, Res Ctr, Hamilton, ON, Canada Hamilton Civ Hosp Hamilton ON Canada Hosp, Res Ctr, Hamilton, ON, Canada Univ Helsinki, Cent Hosp, Dept Clin Neurosci, Helsinki, Finland Univ Helsinki Helsinki Finland p, Dept Clin Neurosci, Helsinki, Finland Columbia Univ Coll Phys & Surg, Dept Neurol & Publ Hlth Epidemiol, Sergievsky Ctr, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NYUSA 10032 w York, NY 10032 USA Columbia Univ Coll Phys & Surg, Neurol Inst, New York, NY 10032 USA Columbia Univ Coll Phys & Surg New York NY USA 10032 w York, NY 10032 USA Univ Amsterdam, Acad Med Ctr, Dept Clin Epidemiol & Biostat, Amsterdam, Netherlands Univ Amsterdam Amsterdam Netherlands & Biostat, Amsterdam, Netherlands Univ Utrecht, Dept Neurol, Utrecht, Netherlands Univ Utrecht Utrecht Netherlands cht, Dept Neurol, Utrecht, Netherlands
Titolo Testata:
NEUROLOGY
fascicolo: 7, volume: 53, anno: 1999, supplemento:, 4
pagine: S32 - S37
SICI:
0028-3878(199910)53:7<S32:ATVFTE>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
STROKE PREVENTION; ISCHEMIC STROKE; ASPIRIN; TICLOPIDINE; SECONDARY; RISK;
Tipo documento:
Editorial Material
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
14
Recensione:
Indirizzi per estratti:
Indirizzo: Easton, JD Brown Univ, Sch Med, Dept Clin Neurosci, 110 Lockwood St,Suite 324, Providence, RI 02903 USA Brown Univ 110 Lockwood St,Suite 324 Providence RI USA 02903 SA
Citazione:
J.D. Easton et al., "Antiplatelet therapy: Views from the experts", NEUROLOGY, 53(7), 1999, pp. S32-S37

Abstract

Antiplatelet therapy is recommended for stroke prevention in persons with a history of thromboembolic stroke or transient ischemic attack (TIA) that is not of cardiac origin.(1) Aspirin was the first antiplatelet agent to beused in this context and is still the most frequently prescribed preventive treatment for ischemic stroke.(2) However, because the results of clinical studies with aspirin have been inconsistent, the dose of aspirin requiredfor stroke prevention in persons with cerebrovascular disease has been a subject of debate among stroke neurologists. In the present discussion, low-dose aspirin is generally regarded by the experts as equivalent in effectiveness to high-dose aspirin, and its higher tolerability has the potential to significantly increase compliance with long-term therapy. Higher aspirin doses may have clinical utility in particular settings, but this requires further study. Despite the controversy, aspirin is now recognized as the treatment standard against which other antiplatelet agents are compared. Antiplatelet agents that may be more effective than aspirin have now been developed. Although each of these agents has been directly compared with aspirin in a large, randomized clinical trial, the lack of direct comparisons amongthese alternative antiplatelet therapies complicates decisions regarding long-term care of patients with cerebrovascular disease. An international panel of stroke neurologists reports that their selection of antiplatelet therapies for patients with prior history of TIA or stroke depends most heavily on drug efficacy and safety issues and is limited by availability (approval status of alternatives).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 05:27:51