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Titolo:
TONIC PAIN - A SPET STUDY IN NORMAL SUBJECTS AND CLUSTER HEADACHE PATIENTS
Autore:
DIPIERO V; FIACCO F; TOMBARI D; PANTANO P;
Indirizzi:
UNIV ROMA LA SAPIENZA,DEPT NEUROL SCI,CHAIR NEUROL 5,V UNIV 30 I-00185 ROME ITALY
Titolo Testata:
Pain
fascicolo: 2-3, volume: 70, anno: 1997,
pagine: 185 - 191
SICI:
0304-3959(1997)70:2-3<185:TP-ASS>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; POSITRON EMISSION TOMOGRAPHY; COMPUTED-TOMOGRAPHY; XE-133 INHALATION; STIMULUS RATE; MIGRAINE; ACTIVATION; CORTEX; BRAIN; ATTACKS;
Keywords:
TONIC PAIN; COLD WATER PRESSOR TEST; SINGLE PHOTON EMISSION TOMOGRAPHY; CEREBRAL BLOOD FLOW; CLUSTER HEADACHE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
60
Recensione:
Indirizzi per estratti:
Citazione:
V. Dipiero et al., "TONIC PAIN - A SPET STUDY IN NORMAL SUBJECTS AND CLUSTER HEADACHE PATIENTS", Pain, 70(2-3), 1997, pp. 185-191

Abstract

Whether the pathogenesis of cluster headache (CH) is peripheral or central is still matter of debate. An involvement of central structures related to pain perception and modulation, which also causes an alteration of the physiological pattern of pain perception in CH, has been hypothesized. We investigated the pattern of brain response to pain in normal subjects and CH patients by evaluating the cerebral blood flow (CBF) changes using an experimental model of tonic aching pain stimulation, the cold water presser test (CWPT). CBF was assessed quantitatively by the Xe-133 inhalation method and single photon emission tomography (SPET), at rest and during CWPT, as previously described (Di Pieroet al., 1994). CWPT was performed in 12 volunteers and in seven patients with CH. All the CH patients had a left-sided headache and were studied in a headache-free phase out of the cluster period. During CWPT,volunteers showed a significant CBF increase in the contralateral primary sensorimotor (P < 0.001), frontal (P < 0.01) and temporal (P < 0.002) regions and thalamus (P < 0.01) and in the ipsilateral temporal (P < 0.005) and anterior cingulate (P < 0.01) regions. During left-handstimulation (ipsilateral to the headache side) by CWPT in CH patients, CBF changes were significantly lower than those observed in volunteers in the contralateral primary sensorimotor region (P < 0.0005) and thalamus region (P < 0.01). Then were no significant differences in thebrain response observed during the stimulation of the hand contralateral to the headache side. In conclusion, in a headache-free phase out of the cluster period, the pattern of cerebral activation during tonicpain stimulation of the hand ipsilateral to the headache side is critically modified in CH patients in areas which are probably involved inthe detection of the stimulus intensity. This modification may reflect a marker of a biological modification of the pain conveyance system. The fact that it is also present out of the active period of the disease, suggests a possible involvement of central tonic pain mechanisms in the pathogenesis of CH. (C) 1997 International Association for the Study of Pain.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 12:07:34