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Titolo:
The search for neural progenitor cells: prospects for the therapy of neurodegenerative disease
Autore:
Shihabuddin, LS; Palmer, TD; Gage, FH;
Indirizzi:
Salk Inst Biol Studies, Genet Lab, La Jolla, CA 92037 USA Salk Inst Biol Studies La Jolla CA USA 92037 Lab, La Jolla, CA 92037 USA
Titolo Testata:
MOLECULAR MEDICINE TODAY
fascicolo: 11, volume: 5, anno: 1999,
pagine: 474 - 480
SICI:
1357-4310(199911)5:11<474:TSFNPC>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL-NERVOUS-SYSTEM; EPIDERMAL GROWTH-FACTOR; ADULT MAMMALIAN FOREBRAIN; STEM-CELLS; PRECURSOR CELLS; SUBEPENDYMAL CELLS; MOUSE BRAIN; SPINAL-CORD; IN-VIVO; NEURONS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
35
Recensione:
Indirizzi per estratti:
Indirizzo: Shihabuddin, LS Salk Inst Biol Studies, Genet Lab, 10010 N Torrey Pines Rd, La Jolla, CA 92037 USA Salk Inst Biol Studies 10010 N Torrey Pines Rd La Jolla CA USA 92037
Citazione:
L.S. Shihabuddin et al., "The search for neural progenitor cells: prospects for the therapy of neurodegenerative disease", MOL MED TOD, 5(11), 1999, pp. 474-480

Abstract

The etiology of many neurodegenerative diseases has been identified in recent years. Treatment of central nervous system (CNS) disease could focus onone or more steps that lead to cell loss. In the past decade, cell therapyand/or ex vivo gene therapy have emerged as possible strategies for the treatment of neurodegenerative diseases. The ability to grow CNS-derived neural progenitor cells using growth factors has been extremely useful to studydiverse phenomena including lineage choice, commitment and differentiation. By virtue of their biological properties and their presence in the adult CNS, neural progenitors represent good candidates for multiple cell-based therapies for neural diseases. Further identification of the molecules that direct the differentiation of adult neural progenitors may allow their activation in vivo to induce self-repair. This review addresses the nature, distribution and regulation of neural stem cells and the potential for applying these cells to Both structural CNS repair and gene therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 19:03:29