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Titolo:
TEMPORAL CHANGES IN THE ACTIVATED PROTEIN-C RESISTANCE RATIO IN A HETEROZYGOTE FOR FACTOR-V-LEIDEN ARE ABOLISHED BY DILUTION IN FACTOR V-DEFICIENT PLASMA
Autore:
MEYER T; GARCIA M; HELMS E; FRANCIS DA; FRANCIS JL;
Indirizzi:
FLORIDA HOSP MED CTR,WALT DISNEY MEMORIAL CANC INST,HEMOSTASIS & THROMBOSIS RES LAB ALTAMONTE SPRINGS FL 32701 FLORIDA HOSP MED CTR,WALT DISNEY MEMORIAL CANC INST,HEMOSTASIS & THROMBOSIS RES LAB ALTAMONTE SPRINGS FL 32701
Titolo Testata:
Clinical and applied thrombosis/hemostasis
fascicolo: 2, volume: 3, anno: 1997,
pagine: 99 - 101
SICI:
1076-0296(1997)3:2<99:TCITAP>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
APC-RESISTANCE; ANTICOAGULANT;
Keywords:
THROMBOSIS; ACTIVATED PROTEIN C RESISTANCE; LABORATORY EVALUATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
8
Recensione:
Indirizzi per estratti:
Citazione:
T. Meyer et al., "TEMPORAL CHANGES IN THE ACTIVATED PROTEIN-C RESISTANCE RATIO IN A HETEROZYGOTE FOR FACTOR-V-LEIDEN ARE ABOLISHED BY DILUTION IN FACTOR V-DEFICIENT PLASMA", Clinical and applied thrombosis/hemostasis, 3(2), 1997, pp. 99-101

Abstract

Activated protein C resistance (APCR) is the single most common causeof hereditary thrombophilia and is caused by a mutation in the factorV molecule (FV Leiden). Screening for this defect has become a standard part of the laboratory evaluation of thrombophilia. However, the original APTT-based screening test does not discriminate completely between normal individuals and heterozygotes for FV Leiden. Diluting the patient's plasma in factor V-deficient plasma greatly improves the predictive ability of this test for the FV Leiden mutation. In this reportwe show that a heterozygote for FV Leiden (confirmed by DNA analysis)showed marked temporal variation in APCR ratio when tested by the original coagulation-based technique. Specifically, this individual tested normal in five of seven occasions tested (APCR ratio range 1.98-2.53; normal >2.0). Using the modified method, although some temporal variation remained, the diagnosis of APCR would have been made on every occasion (APCR ratio 1.85-2.12; normal >2.3). These findings constitute a further reason to use the modified procedure for APCR screening.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 09:57:38