Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
The role of dendritic filtering in associative long-term synaptic plasticity
Autore:
Sourdet, V; Debanne, D;
Indirizzi:
CNRS, Unite Neurocybernet Cellulaire, UPR 9041, F-13009 Marseille, France CNRS Marseille France F-13009 laire, UPR 9041, F-13009 Marseille, France
Titolo Testata:
LEARNING & MEMORY
fascicolo: 5, volume: 6, anno: 1999,
pagine: 422 - 447
SICI:
1072-0502(199909/10)6:5<422:TRODFI>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
CA1 PYRAMIDAL NEURONS; RAT HIPPOCAMPAL SLICE; ACTIVITY-DEPENDENT ATTENUATION; PROPAGATING ACTION-POTENTIALS; VISUAL CORTICAL EPIGENESIS; CEREBELLAR PURKINJE-CELLS; SODIUM ACTION-POTENTIALS; SOURCE-DENSITY ANALYSIS; PERFORATED PATCH-CLAMP; APICAL DENDRITES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
133
Recensione:
Indirizzi per estratti:
Indirizzo: Sourdet, V CNRS, Unite Neurocybernet Cellulaire, UPR 9041, F-13009 Marseille, France CNRS Marseille France F-13009 9041, F-13009 Marseille, France
Citazione:
V. Sourdet e D. Debanne, "The role of dendritic filtering in associative long-term synaptic plasticity", LEARN MEM, 6(5), 1999, pp. 422-447

Abstract

Several forms of synaptic plasticity in the neocortex and hippocampus depend on the temporal coincidence of presynaptic activity and. postsynaptic trains of action potentials (APs). This requirement is consistent with the Hebbian, or correlational, type of cellular learning rule used. in many studies of associative synaptic plasticity. Recent experimental evidence suggests that APs initiated in the axosomatic area are actively back-propagated tothe dendritic arborization of neocortical and pyramidal cells. High-frequency trains of postsynaptic APs that are used as conditioning stimuli for the induction of Hebbian-like plasticity in both neocortical and hippocampal pyramidal cells display attenuation of the dendritic AP amplitude during the train. This attenuation has been shown to be modulated by neurotransmitters and by electrical activity. We suggest here that both spike train attenuation in the dendrite and its modulation by neurotransmitters and electrical activity may have important functional. consequences on the magnitude and/or the sign of the synaptic plasticity induced by a Hebbian pairing procedure.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/03/20 alle ore 21:08:04