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Titolo:
Distribution and intracellular localization of a mouse homologue of Ca2+/calmodulin-dependent protein kinase I beta 2 in the nervous system
Autore:
Ueda, T; Sakagami, H; Abe, K; Oishi, I; Maruo, A; Kondo, H; Terashima, T; Ichihashi, M; Yamamura, H; Minami, Y;
Indirizzi:
Kobe Univ, Sch Med, Dept Biochem, Chuo Ku, Kobe, Hyogo 6500017, Japan KobeUniv Kobe Hyogo Japan 6500017 m, Chuo Ku, Kobe, Hyogo 6500017, Japan Kobe Univ, Sch Med, Dept Anat, Chuo Ku, Kobe, Hyogo 6500017, Japan Kobe Univ Kobe Hyogo Japan 6500017 t, Chuo Ku, Kobe, Hyogo 6500017, Japan Kobe Univ, Sch Med, Dept Dermatol, Chuo Ku, Kobe, Hyogo 6500017, Japan Kobe Univ Kobe Hyogo Japan 6500017 l, Chuo Ku, Kobe, Hyogo 6500017, Japan Tohoku Univ, Grad Sch Med Sci, Dept Cell Biol, Div Histol, Sendai, Miyagi 980, Japan Tohoku Univ Sendai Miyagi Japan 980 Div Histol, Sendai, Miyagi 980, Japan Kumamoto Univ, Sch Med, Inst Mol Embryol & Genet, Kumamoto 860, Japan Kumamoto Univ Kumamoto Japan 860 ol Embryol & Genet, Kumamoto 860, Japan
Titolo Testata:
JOURNAL OF NEUROCHEMISTRY
fascicolo: 5, volume: 73, anno: 1999,
pagine: 2119 - 2129
SICI:
0022-3042(199911)73:5<2119:DAILOA>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERINE THREONINE KINASE; DEVELOPING RAT-BRAIN; IL-2 RECEPTOR; MATURE RATS; PC12 CELLS; ACTIVATION; PHOSPHORYLATION; IDENTIFICATION; PURIFICATION; EXPRESSION;
Keywords:
mouse Ca2+/calmodulin-dependent protein; kinase I beta 2; developmental expression; intracellular localization; signal transduction; neuronal differentiation; neuronal function;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Minami, Y Kobe Univ, Sch Med, Dept Biochem, Chuo Ku, 7-5-1 Kusunoki Cho, Kobe, Hyogo6500017, Japan Kobe Univ 7-5-1 Kusunoki Cho Kobe Hyogo Japan 6500017 017, Japan
Citazione:
T. Ueda et al., "Distribution and intracellular localization of a mouse homologue of Ca2+/calmodulin-dependent protein kinase I beta 2 in the nervous system", J NEUROCHEM, 73(5), 1999, pp. 2119-2129

Abstract

Ca2+/calmodulin-dependent protein kinases (CaMKs) are believed to play important roles in the development and function of the nervous system. We report here the identification and expression of mouse CaMKI beta (mCaMKl beta), in particular mCaMKl beta 2, an isoform of mCaMKl beta. During embryogenesis, the mCaMKI beta 2 gene is expressed mainly in the nervous system, including brain, spinal cord, trigeminal ganglion, and retina. Within the CNS, the expression of mCaMKIb2 is detected in the mantle zone, but not in the ventricular zone, suggesting its possible involvement in the differentiationof neurons. In the adult brain, mCaMKI beta 2 transcripts are detected at high levels in the anterior olfactory nuclei, piriform cortex, septal nuclei, bed nuclei of the stria terminalis, hippocampal pyramidal cells, dentategranule cells, amygdala, hypothalamic nuclei, parabrachial nucleus, and nucleus of the solitary tract. The distinct gene expression pattern suggests that mCaMKI beta 2 may also be involved in different mature neuronal functions from other CaMKs. In addition, mCaMKl beta 2 proteins are localized to the cytoplasm and nuclei, but not to nucleoli, suggesting that mCaMKI beta 2 proteins might be involved in the cytoplasmic and nuclear signal transduction of the nervous system.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 31/03/20 alle ore 22:01:32