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Titolo:
Induction of ventricular fibrillation by T wave shocks: Observations from monophasic action potential recordings
Autore:
Shepard, RK; Wood, MA; Dan, D; Clemo, HF; Gilligan, DM; Ellenbogen, KA;
Indirizzi:
Virginia Commonwealth Univ, Med Coll Virginia, Dept Med, Div Cardiol, Richmond, VA 23298 USA Virginia Commonwealth Univ Richmond VA USA 23298 , Richmond, VA 23298 USA McGuire Vet Adm Med Ctr, Richmond, VA USA McGuire Vet Adm Med Ctr Richmond VA USA et Adm Med Ctr, Richmond, VA USA
Titolo Testata:
JOURNAL OF INTERVENTIONAL CARDIAC ELECTROPHYSIOLOGY
fascicolo: 4, volume: 3, anno: 1999,
pagine: 335 - 340
SICI:
1383-875X(199912)3:4<335:IOVFBT>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
UPPER-LIMIT; DEFIBRILLATION THRESHOLD; VULNERABILITY; HUMANS; STRENGTH;
Keywords:
ventricular fibrillation; monophasic action potential; ventricular repolarization;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
12
Recensione:
Indirizzi per estratti:
Indirizzo: Shepard, RK Virginia Commonwealth Univ, Med Coll Virginia, Dept Med, Div Cardiol, POB 980053, Richmond, VA 23298 USA Virginia Commonwealth Univ POB 980053 Richmond VA USA 23298 SA
Citazione:
R.K. Shepard et al., "Induction of ventricular fibrillation by T wave shocks: Observations from monophasic action potential recordings", J INTERV C, 3(4), 1999, pp. 335-340

Abstract

Introduction: Shocks given during the vulnerable period of cardiac repolarization may induce ventricular fibrillation (VF). However, the relationshipof the vulnerable period and the monophasic action potential (MAP) has notyet been reported in humans. The purpose of this study was, therefore, to determine how the monophasic action potential recorded from the right ventricle correlates with inducibility of VF using T wave shocks during ventricular pacing. Methods: Eleven patients undergoing implantable cardioverter defibrillator(ICD) implantation had a MAP catheter positioned in the right ventricle (RV). The local monophasic action potential duration at 90% repolarization (MAP90) duration was measured during pacing at 400 ms. VF induction was attempted by pacing at 400 ms for 10 cycles and then giving a 1.0 joule monophasic T wave shock at varying coupling intervals (CI) to the last paced stimulus. The maximum and minimum CI that induced VF were determined and mapped in relation to the MAP90 recording. Results: The average paced MAP duration was 275 +/- 20ms. The minimum and maximum CI to induce VF were 255 +/- 24ms and 325 +/- 36ms respectively. This ranged from 93% to 118% of the MAP90 duration but because of delay in conduction time to the MAP catheter, shocks that induced ventricular fibrillation occurred between 74% and 99% of local repolarization time. Conclusion: VF is inducible with low energy T wave shocks falling during the last 25% of the right ventricular MAP90 recording. This corresponds withVF initiation during phase III repolarization.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/09/20 alle ore 14:43:08