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Titolo:
Immunity to breast cancer in mice immunized with X-irradiated breast cancer cells modified to secrete IL-12
Autore:
Carr-Brendel, V; Markovic, D; Smith, M; Taylor-Papadimitriou, JT; Cohen, EP;
Indirizzi:
Univ Illinois, Dept Immunol & Microbiol MC790, Chicago, IL USA Univ Illinois Chicago IL USA Immunol & Microbiol MC790, Chicago, IL USA Imperial Canc Res Fund Labs, London, England Imperial Canc Res Fund Labs London England s Fund Labs, London, England
Titolo Testata:
JOURNAL OF IMMUNOTHERAPY
fascicolo: 5, volume: 22, anno: 1999,
pagine: 415 - 422
SICI:
1524-9557(199909)22:5<415:ITBCIM>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Soggetto:
LASTING ANTITUMOR IMMUNITY; GAMMA-INTERFERON GENE; TUMOR-NECROSIS-FACTOR; MICROSATELLITE INSTABILITY; T-LYMPHOCYTES; ANTIMETASTATIC ACTIVITY; RETROVIRAL VECTOR; INTERLEUKIN-12; IMMUNOTHERAPY; ADENOCARCINOMA;
Keywords:
breast cancer; immunotherapy; immunity; IL-12; mice;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
44
Recensione:
Indirizzi per estratti:
Indirizzo: Cohen, EP Univ Illinois, Dept Immunol & Microbiol MC790, 835 S Wolcott Ave, Chicago,IL USA Univ Illinois 835 S Wolcott Ave Chicago IL USA , Chicago,IL USA
Citazione:
V. Carr-Brendel et al., "Immunity to breast cancer in mice immunized with X-irradiated breast cancer cells modified to secrete IL-12", J IMMUNOTH, 22(5), 1999, pp. 415-422

Abstract

A mouse mammary adenocarcinoma cell line (410.4) originating in a BALB/c mouse, was transduced with a retroviral vector (TGF-mIL-12-Neo) that encodedmurine IL-12. After confirmation of IL-12-secretion, the cells were testedfor their tumorigenic properties in BALB/c mice. The results indicated that unlike other tumors modified for cytokine secretion, modification of 410.4 cells to secrete IL-12 (410.4-IL-12 cells) failed to eliminate the cells'neoplastic growth properties. Progressively growing tumors of 410.4-IL-12 cells invariably formed in syngeneic BALB/c mice and led, eventually, to the animals' death. However, the cells' immunogenic properties were preservedas indicated by the finding that immunizations with 410.4-IL-12 cells, inactivated before injection by X-irradiation, resulted in potent, long-term immunity toward unmodified 410.4 cells and protected the mice against the malignant proliferation of the breast cancer cells. We conclude that modification of 410.4 cells for IL-12-secretion augmented the response of syngeneicBALB/c mice to weakly immunogenic tumor-associated antigens expressed by the cells. The increase in the cells' immunogenic properties, however, was insufficient to prevent tumor growth in the mice. The results point toward the immunotherapeutic potential of X-irradiated tumor cells modified for thesecretion of immune augmenting cytokines.

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Documento generato il 16/07/20 alle ore 16:35:46