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Titolo:
Prognostic value of the soluble interleukin-2 receptor in chronic hepatitis C treated with interferon-alfa
Autore:
Naveau, S; Balian, A; Degos, F; Daurat, V; Chevret, S; Gayno, S; Bastie, A; Riachi, G; Bartolomei-Portal, I; Barange, K; Moussalli, J; Bailly, F; Chaumet-Riffaud, P; Emilie, D;
Indirizzi:
Hop Antoine Beclere, Serv Hepatogastroenterol, F-92141 Clamart, France HopAntoine Beclere Clamart France F-92141 erol, F-92141 Clamart, France Hop Beaujon, Serv Hepatogastroenterol, Clichy, France Hop Beaujon ClichyFrance jon, Serv Hepatogastroenterol, Clichy, France Assistance Publ Hop Paris, GERMED, Delegat Rech Clin, Paris, France Assistance Publ Hop Paris Paris France Delegat Rech Clin, Paris, France Hop Rene Dubos, Serv Hepatogastroenterol, Pontoise, France Hop Rene DubosPontoise France rv Hepatogastroenterol, Pontoise, France Hop St Louis, Dept Biostat & Med Informat, St Louis, France Hop St Louis St Louis France t Biostat & Med Informat, St Louis, France Hop Henri Mondor, Serv Hepatogastroenterol, F-94010 Creteil, France Hop Henri Mondor Creteil France F-94010 enterol, F-94010 Creteil, France Hop Charles Nicolle, Grp Rech Appareil Digest, Rouen, France Hop Charles Nicolle Rouen France rp Rech Appareil Digest, Rouen, France Hop Concept, Serv Hepatogastroenterol, Marseille, France Hop Concept Marseille France erv Hepatogastroenterol, Marseille, France Hop Purpan, Serv Hepatogastroenterol, Toulouse, France Hop Purpan Toulouse France , Serv Hepatogastroenterol, Toulouse, France Hop La Pitie Salpetriere, Serv Hepatogastroenterol, Paris, France Hop La Pitie Salpetriere Paris France epatogastroenterol, Paris, France Hotel Dieu, Serv Hepatogastroenterol, Lyon, France Hotel Dieu Lyon France tel Dieu, Serv Hepatogastroenterol, Lyon, France
Titolo Testata:
JOURNAL OF HEPATOLOGY
fascicolo: 4, volume: 31, anno: 1999,
pagine: 612 - 617
SICI:
0168-8278(199910)31:4<612:PVOTSI>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
SERUM LEVELS; VIRUS-INFECTION; ALPHA; CYTOKINES;
Keywords:
alfa-interferon; chronic hepatitis C; HCV RNA; prognostic factors; soluble interleukin 2 receptor;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
17
Recensione:
Indirizzi per estratti:
Indirizzo: Naveau, S Hop Antoine Beclere, Serv Hepatogastroenterol, 157 Rue Porte Trivaux, F-92141 Clamart, France Hop Antoine Beclere 157 Rue Porte Trivaux Clamart France F-92141
Citazione:
S. Naveau et al., "Prognostic value of the soluble interleukin-2 receptor in chronic hepatitis C treated with interferon-alfa", J HEPATOL, 31(4), 1999, pp. 612-617

Abstract

Background/Aims: High serum levels of the soluble interleukin 2 receptor (sIL-2R) have been reported in patients with chronic hepatitis C, The aims of this study were to determine the evolution of sIL-2R considered as an indicator of activation of T cells in patients with hepatitis C virus (HCV) treated with IFN alpha and to correlate sIL-2R serum levels with parameters reflecting ongoing liver disease and with outcome of interferon treatment. Methods: In a case-control study, we studied patients enrolled in a multicenter randomized clinical trial which had demonstrated the benefit of a reinforced regimen of interferon a, Each of the 26 sustained virological responders (SVR) was paired for treatment regimen with two non-responders (NR). Results: Prior to treatment, higher levels of sIL-2R were found in the sera of 78 patients compared with healthy controls (3791+/-210 pg/ml versus 956+/-88 pg/ml (p<0.001)), In the 78 patients after 4 weeks of treatment, thelevels of sIL-2R were higher than pretreatment levels (4308+/-206 pg/ml (p<0.01)), In the NR, levels of sIL-2R increased significantly after 4 weeks of treatment compared with pretreatment levels (p<0.01), and levels of sIL-2R at week 72 were not significantly different from those at pretreatment. Conversely, in the SVR, levels of sIL-2R at week 4 did not significantly increase compared to pretreatment values, and thereafter gradually decreased. At week 72, levels of sIL-2R were significantly lower than before treatment (p<0.001), The difference between levels of sIL-2R at week 4 and before initiation of treatment (Delta s IL-2R) was smaller in the SVR than in the NR (142+/-219 pg/ml versus 704 +/- 107 pg/ml (p <0.02)), The disappearance of HCV RNA from the serum at week 4 showed a sensitivity of 92% (95% confidence interval 86-98) and a specificity of 60% (95% confidence interval 49-71), Delta sIL-2R had a sensitivity of 42% (95% confidence interval 31-53) and a specificity of 81% (95% confidence interval 79-90) for the prediction of a sustained virological response 6 months after stopping treatment, The disappearance of HCV RNA from serum at week 4 and Delta sIL-2R were independent and early predictive factors for a sustained virological response 6 months after stopping treatment,Conclusions: At week 4, Delta sIL-2R may be a more specific parameter thanthe disappearance of HCV RNA for assessing total, and hence more sustained, elimination of HCV infection 6 months after stopping treatment.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:07:01