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Titolo:
Acute parvovirus B19 infection in connection with a flare of systemic lupus erythematodes in a female patient
Autore:
Hemauer, A; Beckenlehner, K; Wolf, H; Lang, B; Modrow, S;
Indirizzi:
Univ Regensburg, Inst Med Mikrobiol & Hyg, D-93053 Regensburg, Germany Univ Regensburg Regensburg Germany D-93053 , D-93053 Regensburg, Germany Univ Klinikum Regensburg, Klin & Poliklin Innere Med 1, D-93053 Regensburg, Germany Univ Klinikum Regensburg Regensburg Germany D-93053 Regensburg, Germany
Titolo Testata:
JOURNAL OF CLINICAL VIROLOGY
fascicolo: 1, volume: 14, anno: 1999,
pagine: 73 - 77
SICI:
1386-6532(199909)14:1<73:APBIIC>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
EPSTEIN-BARR-VIRUS; ANTIBODIES; SEQUENCE; PROTEIN;
Keywords:
NS1-specific IgG; parvovirus B19; systemic lupus erythematodes (SLE);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
22
Recensione:
Indirizzi per estratti:
Indirizzo: Modrow, S Univ Regensburg, Inst Med Mikrobiol & Hyg, Franz Josef Str Allee11, D-93053 Regensburg, Germany Univ Regensburg Franz Josef Str Allee 11 Regensburg Germany D-93053
Citazione:
A. Hemauer et al., "Acute parvovirus B19 infection in connection with a flare of systemic lupus erythematodes in a female patient", J CLIN VIRO, 14(1), 1999, pp. 73-77

Abstract

Background: Since its discovery parvovirus B19-infections could be linked to a growing variety of diseases. Besides the harmless exanthema erythema infectiosum perferentially observed with B19-infections in childhood a panelof rather serious and also chronic courses that may be associated with anemia, thrombocytopenia, arthritis and others have been described. Objective:In a 26-year-old female patient an acute parvovirus B19-infection was followed by a serious episode of systemic lupus erythematosus (SLE). Here we demonstrate the clinical and serological parameters which were observed in the patient during that episode in addition to the nucleotide sequence of thevirus isolate. Results and conclusion: In this patient parvovirus B19 was not the initial causative agent for SLE. However the B19 infection was followed by a severe flare of SLE and therefore may be considered as an enhancer of the autoimmune disease. The amount of nucleotide variability observed in the viral genome was in the range known from other B19 isolates. An elevated degree of mutations in antigenic domains was not detectable. Therefore, we would like to emphasize the possible role of parvovirus B19 in the aetiology or the enhancement of autoimmune diseases like SLE and the necessityof an according differential diagnosis. (C) 1999 Elsevier Science B.V. Allrights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 06:54:12