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Titolo:
Herpesvirus DNA is frequently detected in liver tissue from hepatitis C patients
Autore:
Cermelli, C; Concari, M; Pietrosemoli, P; Meacci, M; Sabbatini, AMT; Divincenzo, A; Carubbi, F; Loria, P; Bagni, A; Carulli, N; Portolani, M;
Indirizzi:
Univ Modena, Dept Hyg Microbiol & Biostat, I-41100 Modena, Italy Univ Modena Modena Italy I-41100 robiol & Biostat, I-41100 Modena, Italy Univ Hosp Modena, Dept Internal Med, I-41100 Modena, Italy Univ Hosp Modena Modena Italy I-41100 nternal Med, I-41100 Modena, Italy Univ Hosp Modena, Ctr Diag Viral Dis, I-41100 Modena, Italy Univ Hosp Modena Modena Italy I-41100 g Viral Dis, I-41100 Modena, Italy Univ Hosp Modena, Dept Morphol Sci & Forens Med, I-41100 Modena, Italy Univ Hosp Modena Modena Italy I-41100 Forens Med, I-41100 Modena, Italy
Titolo Testata:
JOURNAL OF CLINICAL VIROLOGY
fascicolo: 1, volume: 14, anno: 1999,
pagine: 9 - 16
SICI:
1386-6532(199909)14:1<9:HDIFDI>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
POLYMERASE CHAIN-REACTION; BARR-VIRUS-INFECTION; TRANSPLANT RECIPIENTS; FULMINANT-HEPATITIS; PERIPHERAL-BLOOD; INFANT; CYTOMEGALOVIRUS; PREVALENCE; ANTIBODIES; POPULATION;
Keywords:
herpesvirus; HHV-6; HHV-7; EBV; CMV; hepatitis; PCR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
39
Recensione:
Indirizzi per estratti:
Indirizzo: Cermelli, C Univ Modena, Dept Hyg Microbiol & Biostat, Via Campi 287, I-41100 Modena, Italy Univ Modena Via Campi 287 Modena Italy I-41100 Modena, Italy
Citazione:
C. Cermelli et al., "Herpesvirus DNA is frequently detected in liver tissue from hepatitis C patients", J CLIN VIRO, 14(1), 1999, pp. 9-16

Abstract

Background and aims: Herpesviruses infect the liver and cause minor hepatitis. Our aim is to verify the presence of herpesviruses in the liver from hepatitis C patients and the possible influence of these viruses in the liver disease. Methods: We searched for herpesvirus DNA in liver biopsies from patients with hepatitis C and from a control group without hepatitis by means of nested polymerase chain reaction. Serological investigations were carried out as well. Results: Thirty-four liver specimens from hepatitis C patients were examined, 12 of which (35.3%) were positive for at least one herpesvirus DNA, whereas among the 19 control specimens only two were positive (10.5%; P = 0.049). Liver biopsies from seven patients, three with acute hepatitis of unknown origin, three with non-alcoholic steatohepatitis and one with autoimmunehepatitis were also investigated and three positive samples were found. Conclusions: The prevalence of herpesvirus DNA was found higher in patients with hepatitis C than in individuals without hepatitis. The influence of herpesviruses on the clinical course of hepatitis C is considered. (C) 1999Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 02:35:35