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Titolo:
Development of an in vitro digestion method to assess carotenoid bioavailability from meals
Autore:
Garrett, DA; Failla, ML; Sarama, RJ;
Indirizzi:
Univ N Carolina, Grad Program Nutr, Greensboro, NC 27412 USA Univ N Carolina Greensboro NC USA 27412 am Nutr, Greensboro, NC 27412 USA
Titolo Testata:
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
fascicolo: 10, volume: 47, anno: 1999,
pagine: 4301 - 4309
SICI:
0021-8561(199910)47:10<4301:DOAIVD>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-CAROTENE; VITAMIN-A; CELL-LINE; DISEASE PREVENTION; IRON AVAILABILITY; ALPHA-CAROTENE; ABSORPTION; HUMANS; PLASMA; VEGETABLES;
Keywords:
in vitro digestion; carotenoid bioavailability; lutein; carotenes; Caco-2 cells;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Agriculture,Biology & Environmental Sciences
Life Sciences
Citazioni:
54
Recensione:
Indirizzi per estratti:
Indirizzo: Failla, ML Univ N Carolina, Grad Program Nutr, POB 26170, Greensboro, NC 27412 USA Univ N Carolina POB 26170 Greensboro NC USA 27412 NC 27412 USA
Citazione:
D.A. Garrett et al., "Development of an in vitro digestion method to assess carotenoid bioavailability from meals", J AGR FOOD, 47(10), 1999, pp. 4301-4309

Abstract

The objective of this study was to develop a model for assessing the bioavailability of carotenoids from meals using an in vitro digestion procedure. A meal was prepared using baby food carrots, spinach, and a meat, plus tomato paste. The aqueous fraction was isolated from digesta to determine the quantity of carotenoids transferred from the food to micelles. The micellarization of lutein (25-40%) exceeded (p < 0.01) that of alpha- and beta-carotene (12-18%) and lycopene (<0.5%). Micellarization of carotenoids was not affected by elimination of the gastric phase of the digestive process. The absence of bile extract prevented the transfer of carotenoids from foods tomicelles, whereas omission of pancreatin only reduced the micellarization of the carotenes. Differentiated cultures of Caco-2 human intestinal cells accumulated 28-46% of micellarized carotenoids from the medium after 6 h. These results support the usefulness of the in vitro digestion process as a rapid and cost-effective model for screening the bioavailability of carotenoids from meals.

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Documento generato il 26/11/20 alle ore 08:21:48