Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
Apoptosis and HIV infection: T-cells fiddle while the immune system burns
Autore:
Goldberg, B; Stricker, RB;
Indirizzi:
Calif Pacific Med Ctr, San Francisco, CA 94108 USA Calif Pacific Med Ctr San Francisco CA USA 94108 Francisco, CA 94108 USA Int DNCB Study Grp, San Francisco, CA USA Int DNCB Study Grp San Francisco CA USA Study Grp, San Francisco, CA USA
Titolo Testata:
IMMUNOLOGY LETTERS
fascicolo: 1, volume: 70, anno: 1999,
pagine: 5 - 8
SICI:
0165-2478(19991001)70:1<5:AAHITF>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
NF-KAPPA-B; IMMUNODEFICIENCY-VIRUS TYPE-1; ICE-LIKE PROTEASES; PROTEIN-KINASE; HIV-1-INFECTED PATIENTS; ACTIVATION; DEATH; DISEASE; TAT; EXPRESSION;
Keywords:
apoptosis; HIV; AIDS; nuclear factor-kappa B; monocyte/macrophages; T-cells;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
46
Recensione:
Indirizzi per estratti:
Indirizzo: Stricker, RB Calif Pacific Med Ctr, 450 Sutter St,Suite 1500, San Francisco, CA 94108 USA Calif Pacific Med Ctr 450 Sutter St,Suite 1500 San Francisco CA USA 94108
Citazione:
B. Goldberg e R.B. Stricker, "Apoptosis and HIV infection: T-cells fiddle while the immune system burns", IMMUNOL LET, 70(1), 1999, pp. 5-8

Abstract

Enhancement of programmed cell death (apoptosis) of CD4 T-cells by human immunodeficiency virus (HIV) is thought to be an important factor in the pathogenesis of HIV disease. Recent studies have cast doubt on this concept, however, portraying apoptosis as a potent antiviral strategy to eliminate infected cells. These studies have shed new light on the role of apoptosis inHIV infection. While cellular and immunologic mechanisms of apoptosis purge the HIV-infected lymphoid cell population, HIV thwarts apoptosis in myeloid cells, particularly monocyte/macrophages. Although HIV protease inhibitor therapy partially reverses the lymphoid cell process, this therapeutic approach fails to counter the persistence of HIV infection in myeloid cells. Thus apoptosis of T-cells may be a futile host attempt to control the spread of HIV while the infection smoulders in monocyte/macrophages. In other words, the antiviral defense system fiddles while the immune system burns. (C) 1999 Published by Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 12:45:41