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Titolo:
Neurobiological correlates of suicidal behaviour
Autore:
Brunner, J; Bronisch, T;
Indirizzi:
Max Planck Inst Psychiat, D-80804 Munich, Germany Max Planck Inst Psychiat Munich Germany D-80804 D-80804 Munich, Germany
Titolo Testata:
FORTSCHRITTE DER NEUROLOGIE PSYCHIATRIE
fascicolo: 9, volume: 67, anno: 1999,
pagine: 391 - 412
SICI:
0720-4299(199909)67:9<391:NCOSB>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
GER
Soggetto:
SEROTONIN TRANSPORTER GENE; RECEPTOR-BINDING-SITES; LOW SERUM-CHOLESTEROL; DEXAMETHASONE SUPPRESSION TEST; CEREBROSPINAL-FLUID MONOAMINE; TRYPTOPHAN-HYDROXYLASE GENE; H-3 IMIPRAMINE BINDING; HUMAN BRAIN POSTMORTEM; 5-HT UPTAKE SITES; REGIONALLY SELECTIVE INCREASES;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
252
Recensione:
Indirizzi per estratti:
Indirizzo: Brunner, J Max Planck Inst Psychiat, Kraepelinstr 10, D-80804 Munich, Germany Max Planck Inst Psychiat Kraepelinstr 10 Munich Germany D-80804
Citazione:
J. Brunner e T. Bronisch, "Neurobiological correlates of suicidal behaviour", F NEUR PSYC, 67(9), 1999, pp. 391-412

Abstract

Studies in postmortem brain tissue from suicide victims show a presynapticserotonergic deficit resulting in compensatory upregulation of postsynaptic 5-HT2 receptors in the prefrontal cortex. Reduced levels of cerebrospinalfluid (CSF) 5-hydroxyindoleacetic acid, the major serotonin metabolite, are associated with violent suicide attempts independent of psychiatric diagnosis and predict future suicide attempts and suicide completion, consistentwith the notion of a biochemical trait. Neuroendocrine challenge tests, platelet studies and a polymorphism in the gene for tryptophan hydroxylase, the rate-limiting enzyme in the biosynthesis of serotonin, suggest that serotonergic activity may be reduced. This serotonergic abnormality might be related to the vulnerability or diathesis for suicidal behaviour by predisposing individuals to impulsive and autoaggressive behaviour. The hypothesis of hyperactivity of the hypothalamic pituitary adrenal axis (HPA) is supported by the postmortem findings of increased CSF corticotropin releasing hormone (CRH) concentrations and reduced CRH receptor binding sites in the frontal cortex of suicide victims (interpreted as downregulation following CRH hypersecretion) and dexamethasone nonsuppression in suicide attempters. Animal studies and in vitro experiments indicate that the HPA system modulatesserotonergic activity. It is hypothesized that the serotonergic alterations potentially result from dysregulation of the HPA system. Data from epidemiological and clinical studies demonstrate that low levels of cholesterol are associated with increased suicide risk. In neuronal membranes cholesterol modulates presynaptic and postsynaptic serotonergic neurotransmission. Inmonkeys dietary cholesterol lowering inhibits central serotonergic activity and predisposes the animals to impulsive and aggressive behaviour. It is speculated that dysregulation of the HPA system and disordered cholesterol metabolism could enhance the serotonergic deficit, thus contributing to a neurobiological vulnerability or diathesis for impulsive and autoaggressive behaviour.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 07:51:12