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Titolo:
Enhanced striatal dopamine D-2 receptor-induced [S-35]GTP gamma S binding after haloperidol treatment
Autore:
Geurts, M; Hermans, E; Maloteaux, JM;
Indirizzi:
Univ Catholique Louvain, Pharmacol Lab, B-1200 Brussels, Belgium Univ Catholique Louvain Brussels Belgium B-1200 B-1200 Brussels, Belgium
Titolo Testata:
EUROPEAN JOURNAL OF PHARMACOLOGY
fascicolo: 2, volume: 382, anno: 1999,
pagine: 119 - 127
SICI:
0014-2999(19991008)382:2<119:ESDDR[>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDUCED BEHAVIORAL SUPERSENSITIVITY; MUSCARINIC CHOLINERGIC RECEPTORS; PROTEIN ALPHA-SUBUNIT; RAT-BRAIN; TARDIVE DYSKINESIAS; ANTIPSYCHOTIC-DRUGS; INDUCED CATALEPSY; D2 DOPAMINE; AGONIST; NEUROLEPTICS;
Keywords:
haloperidol; [S-35]GTP gamma S; agonist-induced; dopamine D-2 receptor density; g-protein coupling; catalepsy;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
52
Recensione:
Indirizzi per estratti:
Indirizzo: Hermans, E Univ Catholique Louvain, Pharmacol Lab, UCL 54-10,Ave Hippocrate 54, B-1200 Brussels, Belgium Univ Catholique Louvain UCL 54-10,Ave Hippocrate 54 Brussels Belgium B-1200
Citazione:
M. Geurts et al., "Enhanced striatal dopamine D-2 receptor-induced [S-35]GTP gamma S binding after haloperidol treatment", EUR J PHARM, 382(2), 1999, pp. 119-127

Abstract

Dopamine receptor-G protein coupling and dopamine D-2 receptor density were assessed in rats treated for 3 weeks with either haloperidol (2 mg/kg; i.p.) or vehicle. After 3 days of withdrawal, agonist-induced guanosine 5'-O-(gamma-[S-35]thio)triphosphate ([S-35]GTP gamma S) and [H-3]spiperone binding were determined in striatal homogenates. Maximal [H-3]spiperone binding was increased (24.8%, P < 0.01) following haloperidol treatment. The efficacy of dopamine and the dopamine D-2 receptor agonist R(-)-10,11-dihydroxy-N-n-propylnorapomorphine (NPA) to induce [S-35]GTP gamma S binding were found to be increased by 24.1% (P < 0.01) and 44.6% (P < 0.001), respectively. When measured in the presence of a saturating concentration of a dopamine D-2 receptor antagonist, the response to dopamine was not significantly affected by haloperidol treatment. In addition, the measurement of haloperidol-induced catalepsy confirmed that the efficient dopamine receptor blockade was followed by a progressive development of dopaminergic supersensitivity. Taken together, these results indicate that a functional pool of dopamine D-2 receptors is increased after prolonged haloperidol administration. (C) 1999 Elsevier Science B.V. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/08/20 alle ore 18:43:40