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Titolo:
Ovulation in plasminogen-deficient mice
Autore:
Ny, A; Leonardsson, G; Hagglund, AC; Hagglof, P; Ploplis, VA; Carmeliet, P; Ny, T;
Indirizzi:
Umea Univ, Dept Med Biosci, S-90187 Umea, Sweden Umea Univ Umea Sweden S-90187 niv, Dept Med Biosci, S-90187 Umea, Sweden Univ Notre Dame, Dept Chem & Biochem, Notre Dame, IN 46556 USA Univ Notre Dame Notre Dame IN USA 46556 Biochem, Notre Dame, IN 46556 USA Ctr Transgene Technol & Gene Therapy, Vlaams Interuniv Inst Biotechnol, B-3000 Louvain, Belgium Ctr Transgene Technol & Gene Therapy Louvain Belgium B-3000 ain, Belgium
Titolo Testata:
ENDOCRINOLOGY
fascicolo: 11, volume: 140, anno: 1999,
pagine: 5030 - 5035
SICI:
0013-7227(199911)140:11<5030:OIPM>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
GONADOTROPIN-INDUCED OVULATION; ACTIVATOR GENE-FUNCTION; NORMAL FEMALE MICE; TISSUE-TYPE; HORMONAL-REGULATION; GRANULOSA-CELLS; RAT OVARY; FOLLICULAR PLASMINOGEN; PERIOVULATORY PERIOD; INHIBITOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Ny, T Umea Univ, Dept Med Biosci, S-90187 Umea, Sweden Umea Univ Umea Sweden S-90187 ept Med Biosci, S-90187 Umea, Sweden
Citazione:
A. Ny et al., "Ovulation in plasminogen-deficient mice", ENDOCRINOL, 140(11), 1999, pp. 5030-5035

Abstract

Many different studies suggest that plasmin generated from plasminogen plays a crucial role in the degradation of the follicular wall at the time of ovulation. We have assessed the physiological relevance of plasmin on ovulation by studying plasminogen-deficient mice. Ovulation efficiency (mean number of ova released per mouse) was determined both in a standardized ovulation model in which 25-day-old immature mice were injected with finite amounts of gonadotropins to induce ovulation and during physiological ovulation using adult normally cycling mice. Our results revealed that the temporal onset of follicular wall rupture (first ova observed in bursa or oviduct) was not delayed in plasminogen-deficient mice during gonadotropin-induced ovulation. However, there was a trend toward slightly reduced ovulation efficiency in the plnsminogen-deficient mice. This reduction was only 13% and notstatistically significant (P = 0.084) and may be connected to a delayed maturation of these mice manifested in reduced body and ovary weights. Duringphysiological ovulation adult plasminogen-deficient mice had normal ovulation efficiency compared with plasminogen wild-type mice. Taken together ourresults indicate that under the conditions used in this study plasmin is not required for efficient follicular rupture or for activation of other proteases involved in this process. Alternatively, the role of plasmin may be effectively compensated for by other mechanisms in the absence of plasmin.

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Documento generato il 27/09/20 alle ore 22:55:29