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Titolo:
Type 2 diabetes and acute myocardial infarction - Angiographic findings and results of an invasive therapeutic approach in type 2 diabetic versus nondiabetic patients
Autore:
Waldecker, B; Waas, W; Haberbosch, W; Voss, R; Steen-Muller, MK; Hiddessen, A; Bretzel, R; Tillmanns, H;
Indirizzi:
Univ Giessen, Zentrum Innere Med, Dept Med, D-35392 Giessen, Germany Univ Giessen Giessen Germany D-35392 Dept Med, D-35392 Giessen, Germany
Titolo Testata:
DIABETES CARE
fascicolo: 11, volume: 22, anno: 1999,
pagine: 1832 - 1838
SICI:
0149-5992(199911)22:11<1832:T2DAAM>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY ANGIOPLASTY; THROMBOLYTIC THERAPY; INTRAVENOUS STREPTOKINASE; IMMEDIATE ANGIOPLASTY; CLINICAL COURSE; MORTALITY; MELLITUS; PROGNOSIS; SURVIVAL; DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
42
Recensione:
Indirizzi per estratti:
Indirizzo: Waldecker, B Univ Giessen, Zentrum Innere Med, Dept Med, Klin Str 36, D-35392 Giessen, Germany Univ Giessen Klin Str 36 Giessen Germany D-35392 en, Germany
Citazione:
B. Waldecker et al., "Type 2 diabetes and acute myocardial infarction - Angiographic findings and results of an invasive therapeutic approach in type 2 diabetic versus nondiabetic patients", DIABET CARE, 22(11), 1999, pp. 1832-1838

Abstract

OBJECTIVE - Mortality in diabetic patients with acute myocardial infarction (MI) is high. The significance of the pretreatment coronary status in ripe 2 diabetic patients with acute MI, as well as the effect of mechanical revascularization using percutaneous transluminal coronary angioplasty (PTCA), has not been establishedRESEARCH DESIGN AND METHODS - an patients with type 2 diabetes and acute MI (n = 54) were prospectively enrolled into a study of immediate coronary angiography to guide PTCA of the occluded infarct vessel. Hospital and Long-term course were assessed and compared with an unselected control group of nondiabetic patients (n = 358) who were enrolled in the same study. RESULTS - Angiography showed that sites of occlusion and acute coronary flow were similar in both groups. Multivessel disease and shock were more common in type 2 diabetic versus nondiabetic patients: 69 vs. 51% and 21 vs. 10% (P < 0.02), respectively Direct PTCA n as successful in >90% in both groups. Mortality after 30 days was 13% in ripe 2 diabetic patients versus 5% in patients without diabetes (P < 0.04). Left ventricular (LV) ejection fraction before discharge was lower in diabetic patients (48 +/- 17 vs. 55 +/-15%, P < 0.05). Mortality 1 year after discharge was 11 vs. 4% in diabeticversus nondiabetic patients (P < 0.02). Multivariate analysis identified type 2 diabetes as an independent risk factor for acute, but not for late, mortalityCONCLUSIONS - Direct PTCA is safe and effective in type 2 diabetic patients with acute MI. Mortality after 30 days in unselected diabetic patients is<15% with this approach. Advanced disease and shock contribute to an increased mortality in ripe 2 diabetic patients with acute MI versus nondiabeticpatients.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/05/20 alle ore 14:34:27