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Titolo:
Lack of association between duration of breast-feeding or introduction of cow's milk and development of islet autoimmunity
Autore:
Couper, JJ; Steele, C; Beresford, S; Powell, T; McCaul, K; Pollard, A; Gellert, S; Tait, B; Harrison, LC; Colman, PG;
Indirizzi:
Womens & Childrens Hosp, Dept Endocrinol, Adelaide, SA, Australia Womens &Childrens Hosp Adelaide SA Australia l, Adelaide, SA, Australia Univ Adelaide, Womens & Childrens Hosp, Dept Paediat, Adelaide, SA, Australia Univ Adelaide Adelaide SA Australia ept Paediat, Adelaide, SA, Australia S Australian Hlth Commiss, Epidemiol Unit, Adelaide, SA, Australia S Australian Hlth Commiss Adelaide SA Australia Adelaide, SA, Australia Royal Melbourne Hosp, Dept Pathol, Melbourne, Vic, Australia Royal Melbourne Hosp Melbourne Vic Australia , Melbourne, Vic, Australia Walter & Eliza Hall Inst Med Res, Autoimmun & Transplantat Div, Melbourne,Vic 3050, Australia Walter & Eliza Hall Inst Med Res Melbourne Vic Australia 3050 , Australia Royal Melbourne Hosp, Dept Diabet Endocrinol & Metab, Melbourne, Vic, Australia Royal Melbourne Hosp Melbourne Vic Australia , Melbourne, Vic, Australia
Titolo Testata:
DIABETES
fascicolo: 11, volume: 48, anno: 1999,
pagine: 2145 - 2149
SICI:
0012-1797(199911)48:11<2145:LOABDO>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
DEPENDENT DIABETES-MELLITUS; IMMUNE-RESPONSE; EARLY EXPOSURE; IDDM; RISK; ANTIBODIES; MORBIDITY; CHILDHOOD; ALBUMIN; PROTEIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Couper, JJ Womens & Childrens Hosp, Dept Endocrinol, N Adelaide, SA 5006, Australia Womens & Childrens Hosp N Adelaide SA Australia 5006 Australia
Citazione:
J.J. Couper et al., "Lack of association between duration of breast-feeding or introduction of cow's milk and development of islet autoimmunity", DIABETES, 48(11), 1999, pp. 2145-2149

Abstract

The hypothesis that early exposure to cow's milk or lack of breast-feedingpredisposes to type 1 diabetes remains controversial. We aimed to determine prospectively the relationship of, first, duration of exclusive breast-feeding and total duration of breast-feeding, and second, introduction of cow's milk protein as infant formula, cow's milk, or dairy products, to the development of islet antibodies in early life. Some 317 children with a first-degree relative with type 1 diabetes were followed prospectively from birth for 29 months (4-73). Mothers kept a home diary and answered infant feeding questionnaires at 6-month intervals. No systematic feeding advice was given. Insulin autoantibodies (normal range <5.5%), anti-GAD antibodies (<5.0U), and anti-IA2 antibodies (<3.0 U) were measured at 6-month intervals. Cox proportional hazards model of survival analysis detected no significant difference between children who did not develop islet antibodies (225 of 317 [71%]), children with one islet antibody raised once (52 of 317 [16.4%]),children with one antibody raised repeatedly (18 of 317 [5.7%]), or children with two or more antibodies raised (22 of 317 [6.9%]), in terms of duration of exclusive breast-feeding, total duration of breast-feeding, or introduction of cow's milk-based infant formulas, cow's milk, or dairy products (relative risk: 0.91-1.09). Four of the children with two or more islet antibodies developed type 1 diabetes. We conclude that there is no prospectiveassociation between duration of breast-feeding or introduction of cow's milk and the development of islet autoimmunity in high-risk children.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/07/20 alle ore 17:08:18