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Titolo:
Reproducibility of methods for assessing baroreflex sensitivity in normal controls and in patients with chronic heart failure
Autore:
Davies, LC; Francis, DP; Jurak, P; Kara, T; Piepoli, M; Coats, AJS;
Indirizzi:
Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, London, England Univ London Imperial Coll Sci Technol & Med London England don, England Acad Sci Czech Republ, Inst Sci Instruments, CS-61264 Brno, Czech RepublicAcad Sci Czech Republ Brno Czech Republic CS-61264 Brno, Czech Republic St Anna Fac Hosp, Dept Internal Med Cardiol 1, Brno, Czech Republic St Anna Fac Hosp Brno Czech Republic ed Cardiol 1, Brno, Czech Republic
Titolo Testata:
CLINICAL SCIENCE
fascicolo: 4, volume: 97, anno: 1999,
pagine: 515 - 522
SICI:
0143-5221(199910)97:4<515:ROMFAB>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
POSTMYOCARDIAL INFARCTION PATIENTS; R-R INTERVAL; MYOCARDIAL-INFARCTION; PHENYLEPHRINE METHOD; HYPERTENSION; MORTALITY;
Keywords:
baroreflex sensitivity; chronic heart failure; reproducibility;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Life Sciences
Citazioni:
28
Recensione:
Indirizzi per estratti:
Indirizzo: Davies, LC Royal Brompton Hosp, Heart Failure Unit, Sydney St, London SW3 6NP, England Royal Brompton Hosp Sydney St London England SW3 6NP , England
Citazione:
L.C. Davies et al., "Reproducibility of methods for assessing baroreflex sensitivity in normal controls and in patients with chronic heart failure", CLIN SCI, 97(4), 1999, pp. 515-522

Abstract

Baroreflex sensitivity (BRS) conveys useful prognostic information in patients with heart disease, yet methods for its quantification suffer from poor reproducibility and test failure in some patients with heart failure. We set out to compare the short-term reproducibility and success rate of four different methods of assessing BRS in normal subjects and patients with chronic heart failure (CHF). A total of 31 patients with CHF and 18 normal controls underwent BRS testing using four techniques: (1) bolus phenylephrine (BRSPhe), (2) alpha-index in both low- and high- frequency bands (BRSalpha LF and BRSalpha HF respectively), (3) the sequence method (BRSSeq), and (4)a new 0.1 Hz controlled-breathing, time-domain analysis method (BRSCbr). Each subject underwent two test episodes with each method on the same day. The average values for BRS in patients and controls respectively were: BRSPhe, 4.4 (+/-4.4) ms/mmHg and 19.8 (+/-11.5) ms/mmHg; BRSalpha LF, 5.6 (+/- 4. 1) ms/mmHg and 15.4 (+/- 5.0) ms/mmHg; BRSalpha HF, 7.1 (+/- 7.0) ms/mmHgand 25.1 (+/-8.3) ms/mmHg; BRSSeq, 7.7 (+/-6.3) ms/mmHg and 22.5 (+/-8.4) ms/mmHg; BRSCbr, 6.6 (+/-5.9) ms/mmHg and 22.8 (+/-10.8) ms/mmHg. The coefficients of variation (S.D. of the difference in repeated values divided by mean) in patients and controls respectively were: BRSPhe, 85.6% and 52.2%; BRSalpha LF, 65.9% and 33.7%; BRSalpha HF, 99.7% and 52.1%; BRSSeq, 30.7% and 40.4%; BRSCbr, 30.7% and 19.6%. The numbers of test failures in patientswere: BRSPhen, 15; BRS alpha LF, 7; BRSalpha HF, 5; BRSSeq, 14; BRSCbr, 1. Of the four techniques assessed for measuring BRS, the controlled breathing time-domain method yielded the best reproducibility and lowest failure rate in controls and in patients with CHF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 29/11/20 alle ore 15:56:13