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Titolo:
Interferon-gamma and CXC chemokine induction by interleukin 12 in renal cell carcinoma
Autore:
Bukowski, RM; Rayman, P; Molto, L; Tannenbaum, CS; Olencki, T; Peereboom, D; Tubbs, R; McLain, D; Budd, GT; Griffin, T; Novick, A; Hamilton, TA; Finke, J;
Indirizzi:
Cleveland Clin Fdn, Dept Hematol, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 ematol, Cleveland, OH 44195 USA Cleveland Clin Fdn, Dept Med Oncol, Cleveland, OH 44195 USA Cleveland ClinFdn Cleveland OH USA 44195 Oncol, Cleveland, OH 44195 USA Cleveland Clin Fdn, Canc Ctr Expt Therapeut Program, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 rogram, Cleveland, OH 44195 USA Cleveland Clin Fdn, Dept Immunol, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 mmunol, Cleveland, OH 44195 USA Cleveland Clin Fdn, Dept Clin Pathol, Cleveland, OH 44195 USA Cleveland Clin Fdn Cleveland OH USA 44195 Pathol, Cleveland, OH 44195 USA Cleveland Clin Fdn, Dept Urol, Cleveland, OH 44195 USA Cleveland Clin FdnCleveland OH USA 44195 t Urol, Cleveland, OH 44195 USA
Titolo Testata:
CLINICAL CANCER RESEARCH
fascicolo: 10, volume: 5, anno: 1999,
pagine: 2780 - 2789
SICI:
1078-0432(199910)5:10<2780:IACCIB>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-INFILTRATING LYMPHOCYTES; STIMULATORY FACTOR NKSF; FAS LIGAND EXPRESSION; T-CELLS; INDUCIBLE PROTEIN-10; MATURATION FACTOR; IMMUNE-RESPONSE; IFN-GAMMA; IN-VIVO; HETERODIMERIC CYTOKINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Clinical Medicine
Citazioni:
60
Recensione:
Indirizzi per estratti:
Indirizzo: Bukowski, RM Cleveland Clin Fdn, Dept Hematol, 9500 Euclid Ave, Cleveland,OH 44195 USA Cleveland Clin Fdn 9500 Euclid Ave Cleveland OH USA 44195 USA
Citazione:
R.M. Bukowski et al., "Interferon-gamma and CXC chemokine induction by interleukin 12 in renal cell carcinoma", CLIN CANC R, 5(10), 1999, pp. 2780-2789

Abstract

Interleukin 12 (IL-12) is known to play an important role in the development of an antitumor response. Its activity has been shown to be dependent upon the intermediate production of IFN-gamma and the influx into the tumor of CD8 lymphocytes. In a murine model, tumor regression induced by IL-12 treatment correlated with IFN-gamma, IP-10, and Mig expression in the tumor bed and was abrogated by antibodies to both chemokines. Here we examined the effects of rHuIL-12 on IFN-gamma and CXC chemokine gene expression in patients with renal cell carcinoma (RCC) in an attempt to determine whether a similar series of molecular events leading to IL-12-mediated tumor regressionin mice is also detectable in humans. As in the murine RENCA model, cultured RCC cells themselves could be induced by IFN-gamma to synthesize IP-10 and Mig mRNA. Explanted RCC produced IFN-gamma and IP-10 mRNA in response toIL-12 treatment, which was consistent with the finding that biopsied RCC tumors from IL-12-treated patients also variably expressed augmented If, elsof those molecules after therapy. Although Mig mRNA was present in the majority of biopsied tumors prior to treatment, both the Mig and IP-10 chemokines as well as IFN-gamma were induced in the peripheral blood mononuclear cells of IL-12-treated patients. Skin biopsies of IL-12-treated patients also all synthesized IP-10 mRNA, This study demonstrates that recombinant human IL-12 therapy of patients with RCC has the potential to induce the expression of gene products within the tumor bed that may contribute to the development of a successful antitumor response.

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Documento generato il 01/12/20 alle ore 08:01:36